loading...
League Logo
NFL
League Logo
NFL
League Logo
CFB
League Logo
NBA
League Logo
CBB
League Logo
NHL
All
  • Loading...
loading...
Sun, Sep 228:25 pm UTCState Farm Stadium
Detroit
Lions
DET
Last 5 ATS
W/L15-2
ATS12-5
O/U9-8-0
FINAL SCORE
20
-
13
Arizona
Cardinals
ARI
Last 5 ATS
W/L8-9
ATS11-6
O/U8-7-2
SPREAD
MONEYLINE
OVER/UNDER
Last 5 ATS
15-2
Win /Loss
8-9
12-5
Spread
11-6
9-8-0
Over / Under
8-7-2
SPREAD
MONEYLINE
OVER/UNDER

Simulation Picks

SPREAD
DET @ ARI
Subscribers Only

Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks

MONEYLINE
DET @ ARI
Subscribers Only

Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks

OVER / UNDER
DET @ ARI
Subscribers Only

Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks

44%
PUBLIC
56%
MONEY
70%
PUBLIC
30%
MONEY
Over57%
PUBLIC
Under43%
Over
MONEY
Under

Understanding Public and Money

Think of 'Public' as the percentage of people betting on each side and 'Money' as how much money is being bet. When there's a big difference between the 'Public' and 'Money' data, it usually means that the more serious bettors (referred to as 'Sharp Money') are favoring a particular side.

Expert Picks

Point SpreadDetroit -3 +100
WIN
Unit1.0
+2577
84-53-4 in Last 141 NFL ATS Picks
+823
25-15-2 in Last 42 DET ATS Picks
Adam's Analysis:

For the first time in a long time, it’s OK to believe in the Cardinals and Kyler Murray. Destruction of the Rams aside, going toe-to-toe at the Bills was impressive, and Murray has been great connecting with Marvin Harrison Jr. and Trey McBride. However, this is a spot where the Lions thrive: coming off a loss early in the season. Detroit boasts the stronger defense and the deeper pedigree (believe it or not), and it got a major wake-up call against Tampa Bay last week. I’m ready to buy on Arizona this season … just not in this matchup. Wait until kickoff and see if you can get -2.5.

Pick Made: Sep 22, 7:40 pm UTC on Caesars
Point SpreadDetroit -3 -105
WIN
Unit1.0
+2007
61-37-3 in Last 101 NFL ATS Picks
Mike's Analysis:

The Lions have not dropped consecutive games since early in the '22 season. What's more, they are 17-9 ATS under coach Dan Campbell, with a similar percentage overall in the season's first three weeks. Shaky clock management cost them last Sunday against Tampa Bay, and they are too talented to let a losing streak happen. Their O-line should dominate the Cardinals' front seven, which ought to generate enough scoring to more than offset the Cardinal's certain scoring.

Pick Made: Sep 22, 4:43 pm UTC on BetMGM
Avatar
Total Passing YardsJared Goff Over 257.5 Total Passing Yards -115
LOSS
Unit0.5
Erik's Analysis:

Overall, golf has been disappointing, but his yards are still there. For some reason, the books have not adjusted and still have his yards in the 250-260 range.over

Pick Made: Sep 22, 4:36 pm UTC on BetMGM
Avatar
Anytime Touchdown ScorerDavid Montgomery Anytime Touchdown Scorer -115
WIN
Unit0.5
Erik's Analysis:

Eventually, I will lose on this prop, but Montgomery is scored in 13 of his last 15. So buying it at even money seems like a value play.

Pick Made: Sep 22, 4:24 pm UTC on BetMGM
Money LineDetroit -147
WIN
Unit1.0
+331
10-6 in Last 16 NFL Picks
+112
9-6 in Last 15 NFL ML Picks
+116
2-1 in Last 3 DET ML Picks
Josh's Analysis:

The Cardinals took advantage of an injury-ravaged Rams club last week, while the Lions have underperformed relative to expectations thus far. This contrast has provided value on a Detroit side that should have a sense of urgency and has the superior firepower in this anticipated shootout.

Pick Made: Sep 22, 3:30 pm UTC on BetRivers
Point SpreadArizona +3 -114
LOSS
Unit1.0
+70
3-2 in Last 5 NFL ATS Picks
+386
5-1 in Last 6 ARI ATS Picks
Bruce's Analysis:

What happened to the 2023 Lions that we were expecting to see from the outset of 2024? Detroit could easily be 0-2 after the opening homestand vs. the Rams and Bucs; only a late score forced OT vs. LA, and Detroit couldn't even do that well vs. Tampa Bay. Thru two games, the Lions have also scored only 18 ppg during regulation time as Jared Goff has yet to gain the same rapport as a year ago with his receivers. Not so the Big Red, looking a bit dynamic, and after continuing their 2023 trend of blowing leads in the Buffalo opener, instead went wire-to-wire in a gleeful romp last week past the nemesis Rams, suggesting 2024 might be different in the desert. Play Cards

Pick Made: Sep 22, 8:08 am UTC on FanDuel
Point SpreadDetroit -3 -105
WIN
Unit1.0
+961
33-21-4 in Last 58 NFL Picks
+524
22-15-4 in Last 41 NFL ATS Picks
+41
5-4-1 in Last 10 DET ATS Picks
Zack's Analysis:

Detroit is fortunate they are not 0-2 on the season. Sometimes getting on the road for the first time can help alleviate some of the early season rust. Detroit gets to face an Arizona Cardinals team that is coming off their most lopsided victory since the 2016 season. Sell high spot here on the Cardinals, as the Lions gut out a tough road win in Arizona.

Pick Made: Sep 22, 3:04 am UTC on Caesars
Point SpreadArizona +3 -115
LOSS
Unit1.0
+853
53-40-2 in Last 95 NFL ATS Picks
+123
20-17-1 in Last 38 DET ATS Picks
Micah's Analysis:

I don't want to put too much into what I saw in the first two games but there's no denying that the Arizona Cardinals are much better with Kyler Murray in the first two games than we've seen. He's playing with the renewed purpose. The Cardinals are 2-0 against a spread and lost the opener barely to Buffalo because they scored on every possession in the second half. But the Cardinals have heart with the running game featuring James Conner and last week they unleashed their number one pick Marvin Harrison Jr who was electric with Murray. I think the Cardinals cover against the Lions who are struggling with their own system.

Pick Made: Sep 21, 7:06 pm UTC on DraftKings
Avatar
Total Receiving YardsMarvin Harrison Jr. Over 59.5 Total Receiving Yards -115
WIN
Unit1.0
+183
3-2 in Last 5 NFL Player Props Picks
Alex's Analysis:

After a Week 1 performance that saw Marvin Harrison fail to make a big impact on the stat sheet, the rookie WR erupted for 130 yards in Week 2 in a game where Kyler Murray only attempted 21 passing attempts. We're likely to see an increase in passing volume in a game with the highest projected total on this weeks slate featuring two explosive offenses. This is also a great matchup for Harrison as Detroit's secondary thus far ranks 24th in EPA per dropback, in addition to 27th in Explosive Pass %.

Pick Made: Sep 20, 8:03 pm UTC on BetMGM
Avatar
Total Rushing YardsKyler Murray Over 32.5 Total Rushing Yards -111
WIN
Unit1.0
+1464
40-22 in Last 62 NFL Player Props Picks
Sia's Analysis:

Kyler Murray has surpassed this total through the first two weeks by a wide margin (59 and 57 rushing yards). The Cardinals are unlikely to run the ball successfully against a stout Lions rush defense which will require them to move the ball through the air. The air attack will lead to a lot of dropbacks and a lot of vintage scrambling from Kyler. Look for him to get out of the pocket and scramble early and often with guys like Hutchinson literally breathing down his neck.

Pick Made: Sep 20, 4:20 am UTC on BetMGM
Point SpreadDetroit -3 +100
WIN
Unit1.0
+866
21-11-1 in Last 33 DET ATS Picks
Larry's Analysis:

The Lions are kicking themselves after going 1 for 7 in the red zone in their Week 2 loss to Tampa Bay. Ben Johnson's offense has not been as crisp as anticipated. But the Detroit attack should look better this week against a mediocre-at-best Arizona defense. The Lions haven't lost back-to-back games since October 2022. Wish I had jumped on the 2.5s that were available earlier, but I still like it at -3 even money.

Pick Made: Sep 20, 2:36 am UTC on Caesars
Avatar
Total Rushing + Receiving YardsJahmyr Gibbs Over 79.5 Total Rushing + Receiving Yards -115
WIN
Unit1.0
+15
4-4 in Last 8 NFL Player Props Picks
Jason's Analysis:

Gibbs looks like he might be getting more of market share, Lions need to get back to basics here with a great OL and road grade a bad run D. You look at how James Cook moved against this D Week 1 (over 100 scrimmage yads) and it screams Gibbs to me. He's averaging 5.2/carry since the start of last season Lions can't get too cute here.

Pick Made: Sep 18, 7:45 pm UTC on BetMGM
Point SpreadDetroit -2.5 -118
WIN
Unit1.0
+1475
55-37 in Last 92 NFL Picks
+775
53-41-1 in Last 95 NFL ATS Picks
+748.5
32-23-2 in Last 57 DET ATS Picks
R.J.'s Analysis:

The Cardinals looked incredible beating up on the Rams in Week 2, but they'll get a healthier Lions team this week coming off a disappointing loss where Jared Goff had his yearly clunker, throwing three picks. The Lions offense should be much better here, controlling the trenches and leaning more on the rushing attack. The Lions defensive front had a field day with the Bucs, with Aidan Hutchison tallying four sacks and D.J. Reader immediately solidifying the rush defense. The lookahead here was Lions -4.5, which I think is about right even with my Cardinals rating upgrade. Once you see -2.5 like we have at DraftKings, grab it.

Pick Made: Sep 17, 3:05 pm UTC on DraftKings

Team Injuries

Detroit Lions
Monday, Dec 15, 2025
Avatar
G
Kayode Awosika
FootQuestionable
Avatar
CB
Amik Robertson
HandQuestionable
Avatar
SAF
Kerby Joseph
KneeQuestionable
Avatar
SAF
Thomas Harper
ConcussionQuestionable
Arizona Cardinals
Monday, Dec 15, 2025
Avatar
G
Evan Brown
PersonalQuestionable
Avatar
SAF
Jalen Thompson
HamstringQuestionable
Avatar
SAF
Dadrion Taylor-Demerson
AnkleQuestionable
Avatar
WR
Xavier Weaver
HamstringQuestionable
Avatar
OT
Paris Johnson Jr.
Knee - MCLQuestionable
Avatar
CB
Max Melton
HeelQuestionable
Avatar
WR
Marvin Harrison Jr.
HeelQuestionable
Sunday, Dec 14, 2025
Avatar
LB
Cody Simon
KneeQuestionable
© 2025 CBS INTERACTIVE INC. ALL RIGHTS RESERVED. SportsLine and SportsLine PRO are registered trademarks of SportsLine.com, Inc.FANS ONLY
In partnership with...247 Sports

FOLLOW US:

The content on this site is for entertainment purposes only and SportsLine makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event. There is no gambling offered on this site. This site contains commercial content and SportsLine may be compensated for the links provided on this site.