FanDuel. Puka Nacua cleared this receptions line in his first five games, before leaving early with an injury in the sixth. He came back last week to catch seven of his eight targets before leaving early with a minor injury in a Rams blowout. Without an injury designation this week, I like Nacua to see his standard 10+ targets against a defense he had his way with in their first meeting (10 catches on 12 targets).

It's going to be a beautiful fall day in San Francisco at 80° with no chance of rain and the wind blowing at 3 mph, which means this is good scoring weather. It's a battle of two six-win teams, with the Rams coming in on a three-game win streak, scoring 34 or more in their last two games. The Rams are the number one passing team in the NFL, with Matthew Stafford producing 258 yards per game with 21 touchdowns and only two interceptions. The question is how many points the 49ers are going to score with Mac Jones, and he'll be fine. The 49ers won a Week 5 game against the Rams, 26-23, and have gone over in five of the last six meetings.

This is one of the model's favorite plays today in regards to an anytime TD -- it only liked Jonathan Taylor and James Cook better among running backs. JT went bonkers this morning in Berlin with 244 yards and three TDs. Christian McCaffrey didn't score when the Niners upset the Rams on Oct. 2 but also got 30 touches between carries and receptions. Pretty confident he scores today if another 30 or so touches.

A half-hundred seems high. Each team has engaged in one game where this total was hit -- the Rams not since Week 3. San Fran ranks 23rd in points scored, with four teams below them having played one fewer game. Mac Jones remains the 49ers QB -- not a significant drop-off from injured regular Brock Purdy but a notch below nonetheless. L.A.'s defense yields the 10th lowest amount of yards. This is a legit rivalry game, the nature of which reduces the chances of a shootout.

Consistency has been a fixture to Davante Adams throughout his career. His role this season for the Rams has not been as flashy as years past, but his route tree is a perfect matchup today against the 49ers. San Francisco is beat up, and expect veteran Matthew Stafford to continue to pepper Adams who has five touchdowns over the last two weeks. After four of five games having sixty yards or less, Adams gets it done in the yardage market.

This is just too many points for the home dog in an NFC West rivalry. Since 2019, the Rams and Niners have faced off 14 times, with the underdog going 13-1 ATS in those matchups! The 49ers have been decimated by injury this season, yet continue to play tough. Backup QB Mac Jones will make the start again, which I don't see as a downgrade considering that he threw for 33/49, 342 yards, 2 TD/0 INT in San Fran's 26-23 OT win over the Rams in Week 5. The Rams also have issues at the Kicker position which could make things funky. I'll take the +6.

Late word has Mac Jones at QB again for San Francisco. Remember, Jones was at the helm of that surprising 26-23 OT win over the Rams at So Fi last month, passing for 342 yards in the process. Proving remarkably resilient his season, the Niners have remained in the NFC West race despite many key injuries, including on defense. SF is maximizing resources as good as any team in the league. If there is one problem for the Rams, and it cost them dearly in the earlier loss to the 49ers, it's the kicking game, and to that end a desperate Sean McVay is turning to a new PK, Harrison Mevis, to take the place of the erratic Joshua Karty. Play 49ers

Kyren Williams hasn't surpassed this rushing total in either of his last two games, but neither of those games were competitive. This division battle should be close, and while Stafford does have the ability to throw it all over the yard, I think the 49ers will respect the pass enough to provide some light boxes for Kyren. Add that Mykel Williams is out for the season and this injury ravaged defense may be even more prone to chunk runs. The expectation is that Kyren gets 15 carries and his success rate and matchup indicate that he'll pass this rushing number.

This is a nice revenge spot for a Rams team that dominated the first meeting but somehow lost. Since that Week 5 game, the 49ers have continued to lose defensive pieces. LA is operating with high efficiency and balance and should make a statement here.

The Rams are looking for revenge after a primetime OT loss in the first meeting, but even with the motivation factor and the 49ers losing another pass rusher I'm surprised this is over 3. Although the Rams defense rates highly, they had trouble slowing down this 49ers attack when it didn't have George Kittle and Jauan Jennings, and it also didn't play as well as a 35-7 final against the Jaguars suggests with four drives of 50+ yards ending on failed fourth downs. Throw in a decided advantage in the kicking game with Josh Karty's struggles Sunday, plus the possibility of trading for DL help, and I like the 49ers catching the hook.