The Steelers have to travel on a short week. ...

Case Keenum is 38 and hasn't played since the 2023 season. With Tyson Bagent available but coming off a concussion, Keenum is expected to start for Chicago. Either way, Vic Fangio's defense -- which could see Jonathan Greenard make his season debut -- should dominate. The Eagles definitely remember giving up 281 rushing yards to Chicago in a 24-15 loss on the Friday after Thanksgiving last year. So far this season, Philly has been beset by poor offensive line play, but that unit took a big step forward in the game-winning 65-yard TD drive last week at Tennessee. I would play this up to -4.

D'Andre Swift is the better receiving back in Chicago. He drew six targets last week, catching five passes for 54 yards. With the Bears potentially playing from behind and Case Keenum likely looking to make quick throws, I expect Swift to get involved as a receiver once again.

The 49ers started the season with a pair of blowouts, while the Cardinals crashed back to earth in Week 2, losing 31-7 at home to Seattle. However, the 49ers' defense doesn't compare to the Seahawks' elite stop unit. And San Francisco is dealing with yet more injuries to its wideouts. Demarcus Robinson (high ankle sprain) is out, while the status of Mike Evans (hip) is unclear. Defensive lineman Romello Height, who had a sack vs. Miami, broke his hand. Look for Jacoby Brissett to bounce back and keep Arizona close.

The Bucs' problems are not a result of Bucky Irving, who has been highly efficient through two games. If anything, he deserves the ball more. He's averaging 5.4 yards per carry. While Minnesota beat Chicago 9-3 last Sunday, the Vikings allowed 134 rushing yards. Kyle Monangai averaged 4.7 yards per carry in that loss. Facing Brian Flores' blitz-heavy scheme, look for the Bucs to feature Irving.

Initially I was leaning toward the Panthers, who scored 71 points in their first two games. But that changed when the first injury reports came out. They contained good news for the Browns and bad news for Carolina. Bryce Young has carved up two bad defenses but both were zone-heavy schemes. Cleveland plays a lot of man coverage and has the corners to match up here. Grab the full field goal

Coaching malpractice and mismanagement prevented the Jets from starting 2-0. But this is a much-improved roster from last season. New York is allowing 4.0 yards per play, third-lowest. The Lions just lost safety Avonte Maddox to a season-ending foot injury, and safeties Brian Branch and Kerby Joseph aren't ready to return yet. This is a great matchup for Geno Smith and Garrett Wilson. Detroit should bounce back from its performance in Buffalo with a win, but this is too many points.

Jets No. 1 receiver Garrett Wilson only has 14 targets through two games. Judging from reports, it's an issue the team wants to correct. Sunday in Detroit would be a good place to start, as the Jets will need a big game from Wilson to keep up. No. 2 receiver Adonai Mitchell is dealing with a finger injury that limited him in practice Thursday. Facing a Lions' defense that's given up the most yards to opposing wideouts, as well as facing his good friend D.J. Reed, look for Wilson to draw about 10 targets and clear this prop total.

Jameson Williams is typically more explosive at home and indoors. Last season he averaged 19.4 yards per catch in Detroit, 15.6 on the road. Now he's back at home in a game that I project to be very competitive. Williams has run the sixth-most routes in the NFL and should put his quiet start behind him Sunday.

Alec Pierce’s absence means the Texans’ defense can focus on stopping Jonathan Taylor. While the Texans likely won’t have Nico Collins again, they should be able to do enough to get to 20 points against a leaky Colts’ defense. This number has come down to the point where there is value on the preseason AFC South favorites.

The Titans averaged a healthy 5.7 yards per play in their heartbreaking loss to Philadelphia. That's a good sign entering Brian Daboll's revenge game at the Giants. Not only is New York going with Jameis Winston, who quite possibly might be washed up, but the G-Men could be without left tackle Andrew Thomas and top pass rusher Brian Burns. And we didn't even mention Malik Nabers' shoulder injury, which he's expected to play through. The 3s are going away so I jumped on Tennessee.

The Seahawks have shut down the Patriots and Cardinals, and I like them to do something similar to the Commanders. Not only is Jayden Daniels out with an elbow injury, Washington's best offensive lineman, Sam Cosmi, is in concussion protocol. Starting defensive tackle Javon Kinlaw also left the loss to Dallas with a shoulder injury, while safety Nick Cross is dealing with internal injuries and had to be hospitalized. Since taking over in Seattle, Mike Macdonald is 13-4-1 ATS on the road, covering by an average of eight points.

The Packers average 3.3 yards per carry and are going pass-heavy. They just lost slot receiver Jayden Reed to a neck injury. When Reed exited the Week 2 loss at the Jets, Tucker Kraft's route participation increased. He finished the game with 84 percent route participation and played nearly every offensive snap. That's significant given his box score, which showed just two catches for 15 yards. Now he gets a great matchup against a Falcons defense that's been burned by lesser talents at tight end, Pat Freirmuth in Week 1 and Darren Waller in Week 2. Tight ends have caught 12 of 13 targets when facing the Falcons, for 114 yards. Jonnu Smith might get a catch or two, but it's Kraft who should erupt.

There were many reasons why the Colts' defense got embarrassed in Week 1. Among them: safety Cam Bynum wore the green dot. Indy's defense had trouble getting lined up properly, including not being set for the first play from scrimmage when Zay Flowers made a 49-yard catch. Defensive coordinator Lou Anarumo is going with LB Akeem Davis-Gaither as his signal caller Sunday night, which should lead to better results. Anarumo has had much more career success vs. Patrick Mahomes than he has against Lamar Jackson. Look for Jonathan Taylor and Alec Pierce to lead the way as the Colts keep this close.

The Seahawks had extra time to get Drew Lock ready for this start against a beatable Arizona defense. Defensively, Seattle held New England to 4.1 yards per play and a miniscule 4.7 yards per pass. Emerging star safety Nick Emmanwori, who missed the season opener with an ankle injury, is practicing and should play Sunday. Back the defending champs to improve to 13-4-1 ATS on the road under Mike Macdonald.