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Sun, Sep 085:00 pm UTCLucas Oil Stadium
Houston
Texans
HOU
Last 5 ATS
W/L10-7
ATS7-10
O/U6-11-0
FINAL SCORE
29
-
27
Indianapolis
Colts
IND
Last 5 ATS
W/L8-9
ATS9-8
O/U9-7-1
SPREAD
MONEYLINE
OVER/UNDER
Last 5 ATS
10-7
Win /Loss
8-9
7-10
Spread
9-8
6-11-0
Over / Under
9-7-1
SPREAD
MONEYLINE
OVER/UNDER

Simulation Picks

SPREAD
HOU @ IND
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Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks

MONEYLINE
HOU @ IND
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OVER / UNDER
HOU @ IND
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43%
PUBLIC
57%
MONEY
83%
PUBLIC
17%
MONEY
Over78%
PUBLIC
Under22%
Over
MONEY
Under

Understanding Public and Money

Think of 'Public' as the percentage of people betting on each side and 'Money' as how much money is being bet. When there's a big difference between the 'Public' and 'Money' data, it usually means that the more serious bettors (referred to as 'Sharp Money') are favoring a particular side.

Expert Picks

Point SpreadIndianapolis +3 +100
WIN
Unit1.0
+393.5
15-9 in Last 24 NFL Picks
+182
3-2 in Last 5 NFL ATS Picks
Daniel's Analysis:

Divisional home underdogs in Week 1 are 22-7 ATS since 2010, and 9-2 ATS since 2018. The Texans come into this season with as much hype as any team, but it does feel a bit rushed. Colts QB Anthony Richardson remains a fairly unknown commodity, but has all the potential in the world as a mobile QB in this Shane Steichen offense. The betting handle is heavy on the Texans, so I'll play the house and take the home dogs. CJ Stroud went just 3-5 ATS as a favorite last year. If Richardson stays healthy, look for the Colts to make noise in the AFC this season.

Pick Made: Sep 08, 4:27 pm UTC on Caesars
Point SpreadHouston -2.5 -120
LOSS
Unit1.0
+2577
84-53-4 in Last 141 NFL ATS Picks
Adam's Analysis:

The Colts play extremely well at home, but Anthony Richardson is basically still a rookie given his limited play in 2023 (and the way he looked in the preseason). The Texans upgraded significantly around C.J. Stroud with Joe Mixon and Stefon Diggs boosting an offense that was already running smoothly. Both teams have the chances to win the AFC South this season, but the Texans might be one of the best teams in the conference.

Pick Made: Sep 08, 4:04 pm UTC on FanDuel
Avatar
Total ReceptionsAdonai Mitchell Over 2.5 Total Receptions -143
LOSS
Unit1.5
Erik's Analysis:

This is -175 on most sites and will be 3.5 soon. A full 1.5 unit play. He’s a emerging player who will exceed expectations

Pick Made: Sep 08, 3:03 pm UTC on BetRivers
Avatar
Total ReceptionsAdonai Mitchell Over 2.5 Total Receptions -143
LOSS
Unit1.0
+183
3-2 in Last 5 NFL Player Props Picks
Alex's Analysis:

Adonai Mitchell looks set for a full time roll and heavy route participation in Week 1 after Colts starting slot receiver Josh Downs has been ruled out versus the Houston Texans. I was impressed with Mitchell’s usage in the preseason as he was able to draw targets from all over the field and looked to be the Colts most explosive receiving option. The Texans boasted an excellent run defense last season and were much more vulnerable through the air. I like Mitchell’s chances of at least 90% route participation and the impressive rookie should draw a healthy target share in the process.

Pick Made: Sep 08, 7:37 am UTC on BetRivers
Point SpreadIndianapolis +3 -115
WIN
Unit1.0
+331
10-6 in Last 16 NFL Picks
+86
2-1 in Last 3 IND ATS Picks
Josh's Analysis:

The Colts were a dropped pass at the goal line away from sneaking into the playoffs last year despite injuries to QB Anthony Richardson and other key players. Now, they' should be improved and are looking for a little payback against a Texans club that was probably a year ahead of schedule last year. They are the trendy pick to win the division, but will face resistance from a Colts club that has its own designs on a breakout season.

Pick Made: Sep 04, 10:29 pm UTC on DraftKings
Point SpreadIndianapolis +3 -115
WIN
Unit1.0
+1475
55-37 in Last 92 NFL Picks
+775
53-41-1 in Last 95 NFL ATS Picks
+1018
28-16-3 in Last 47 IND ATS Picks
R.J.'s Analysis:

These teams played for the division crown in Week 18 last year, with the Texans winning a tight matchup. That the Colts were neck and neck with Houston despite playing most of the year with a backup QB is impressive, and I expect a run game that dominated that Week 18 matchup to be even better with Anthony Richardson back. Shane Steichen should have a field day attacking the Houston run defense. The line in Week 18 was Houston -1.5 in Indy, and now the Colts have their QB back, so I have to think we're getting value catching the full field goal.

Pick Made: Sep 04, 1:12 pm UTC on BetMGM
Point SpreadIndianapolis +2.5 +100
WIN
Unit1.0
+1879
45-24-1 in Last 70 NFL Picks
+1814
39-19-1 in Last 59 NFL ATS Picks
Emory's Analysis:

Before he went out of the game with an injury last season, Anthony Richardson and the Colts were up 14-0 against the Texans. Now, both teams have improved on both sides of the ball this offseason, but there's no reason why the Colts shouldn't be taken seriously in this ball game against a division foe.

Pick Made: Sep 04, 12:37 pm UTC on Caesars
Over / UnderUnder 49.5 -115
LOSS
Unit1.0
+120
4-2 in Last 6 HOU O/U Picks
Erik's Analysis:

I don’t see this game being played in the 50s. Indy will want to run the ball and they play good defense. Plus, I’m not sure Houston is the offensive juggernaut that they hype train is selling. And the Texan D is improved. Divisional game and two good coaches. Under

Pick Made: Sep 03, 5:49 pm UTC on FanDuel
Point SpreadHouston -2.5 -110
LOSS
Unit1.0
Larry's Analysis:

Anthony Richardson may ultimately become a top-flight NFL quarterback, but right now his accuracy and decision-making are lacking. That was evident throughout the preseason, in games and joint practices. The Texans have no such concerns with C.J. Stroud. With the second-year star on a cheap contract, they wisely went all-in this offseason, landing Danielle Hunter (16.5 sacks), Stefon Diggs, Joe Mixon, Folo Fatukasi and Azeez Al-Shaair, among others. Houston won the division last year despite being the NFL's most injured team. The Texans are relatively healthy now and poised for greatness. Look for Indy to fall to 0-10-1 straight-up in its last 11 season openers, and lose by a field goal or more.

Pick Made: Sep 01, 7:56 pm UTC on BetMGM
Money LineIndianapolis +110
LOSS
Unit1.0
+2050
64-38-2 in Last 104 NFL Picks
+264
4-1 in Last 5 NFL ML Picks
Sia's Analysis:

I'm a pretty big fan of the Colts this year and I think they are very live to win the AFC South. They get the Texans at home Week 1 and I think it's a good spot to lean on Anthony Richardson and Jonathan Taylor behind a solid offensive line. I think we're going to see some ball control and bludgeoning at the line of scrimmage, similar to the gameplan that the Ravens undertook against the Texans in the playoffs. The Colts secondary is a question, but they're very solid at almost every other position group. Home team gets the win here.

Pick Made: Aug 05, 6:16 pm UTC on WilliamHillNewJersey

Team Injuries

Houston Texans
Wednesday, Apr 01, 2026
Avatar
TE
Dalton Schultz
CalfQuestionable
Avatar
WR
Justin Watson
ConcussionQuestionable
Avatar
LB
Jake Hansen
ChestQuestionable
Avatar
DB
Ajani Carter
HamstringQuestionable
Wednesday, Feb 11, 2026
Avatar
LB
Azeez Al-Shaair
ThumbQuestionable
Avatar
WR
Tank Dell
Knee - ACL + MCLQuestionable
Avatar
TE
Brevin Jordan
KneeQuestionable
Avatar
TE
Cade Stover
KneeQuestionable
Avatar
CB
Jaylin Smith
KneeQuestionable
Avatar
DT
Kyonte Hamilton
AnkleQuestionable
Indianapolis Colts
Wednesday, Apr 01, 2026
Avatar
OT
Jack Wilson
UndisclosedQuestionable
Avatar
DT
DeForest Buckner
NeckQuestionable
Avatar
SAF
Daniel Scott
KneeQuestionable
Avatar
CB
Charvarius Ward
ConcussionQuestionable
Avatar
TE
Will Mallory
ChestQuestionable
Avatar
CB
Sauce Gardner
CalfQuestionable
Avatar
WR
Anthony Gould
FootQuestionable
Avatar
LB
Hunter Wohler
FootQuestionable
Wednesday, Feb 11, 2026
Avatar
QB
Daniel Jones
AchillesQuestionable
Avatar
OT
Blake Freeland
LegQuestionable
Avatar
K
Spencer Shrader
Knee - ACL + MCLQuestionable
Avatar
QB
Anthony Richardson
EyeQuestionable
Avatar
CB
Justin Walley
Knee - ACLQuestionable
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