The Rams will need a much better defensive effort than they gave last week in that disaster of a loss to the Panthers, but it’s tough to see how the Cardinals can legitimately compete against a team that has the weaponry to put together a dominant performance. This is a perfect bounce-back spot for Los Angeles, whereas Arizona is basically packing it in for the season. The hosts are too one-dimensional offensively, and their once-vaunted secondary has been leaking over the last few weeks. This sets up similarly to the 49ers and Seahawks games; those teams beat the Cardinals by about 20 points each.

Arizona has topped this in every home game this season. The Los Angeles defense has been shaky on the road at times, including last week's shock 31-28 loss at Carolina. Two defensive starters are either questionable or doubtful. Certainly possible the Rams get up big and just go prevent defense. Our model has the Cards at 19 points, and most of our books have this TT at 19.5.

On Friday the Cardinals ruled out Marvin Harrison Jr. and Greg Dortch from this week's game against the Rams. It sets up perfectly for receiver Michael Wilson to reprise his role from Weeks 11 and 12 as the team's No. 1 wideout. In those games he caught 15 and 10 passes for over 100 yards each. The Cardinals have been one of the pass-heaviest offenses since Jacoby Brissett took over under center. I suspect Wilson will see a ton of targets as the Cardinals try to chase points against the explosive Rams. I wouldn't be shy taking this over at 6.5 or 7.5 either.

FanDuel. With Marvin Harrison Jr. ruled out, it’s time to fire up Michael Wilson overs again. Wilson accrued 25 catches on 33 targets in the two games Harrison missed, with a ridiculous 39% first read rate (per Fantasy Points Data). Against the Rams, gamescript should cooperate, and I don’t expect the Cardinals subpar rushing attack against the Rams third ranked run defense (per FTN’s DVOA metric). I have Wilson once again seeing double digit targets.

I bet the high-powered Rams to bounce back from their stunning upset loss at Carolina. Arizona has a bleak injury report and has been blown out by its other two division rivals. LA is at least on the level of Seattle and San Francisco. I would play this at anything less than 10.

Blake Corum has received at least seven carries in six straight games, clearing this rushing total four times. Last week he erupted for 81 yards at Carolina. With the Rams likely to be in clock-killing run mode late, I bet Corum to run for at least 33 yards.

The Rams are coming off a shocking loss to the Panthers, and the defense has proven inconsistent when the opposing QB isn't either playing hurt or giving the ball away at will. The Cardinals ended a streak of eight straight games with 20+ points last week, but a red-zone pick plus a missed field goal led to scoring just 17 points despite their excellent 6.3 yards per play against the Bucs. If the Rams can hold them under 20, they'll be the first to do so all year, but I don't think that defense is playing well enough to pull it off.

The Rams had a wake-up call last week on a cross-country trip, and the market expects a big bounce back this week. But I look at the Cardinals and see a team that remains competitive most weeks with Jacoby Brissett at QB, and they completely outplayed the Bucs last week despite the loss. Arizona's one home loss by more than four points came in a game where they outgained the 49ers by more than 200 yards, and the Rams D has looked a bit soft when the opposing QB isn't melting down. This is a good backdoor cover spot, but if Arizona's defense can get Walter Nolen back this week after Will Johnson returned last week, they could be live for the upset.