With this line coming down to a field goal, I’m willing to back the 49ers in a home spot against a team that has historically struggled travelling to the West Coast. Brock Purdy being back should help the offense, even if it’s still down multiple pass catchers, though the return of Demarcus Robinson should help. Losing Nick Bosa is going to be an issue for the San Francisco defense, but given Jacksonville’s propensity for dropping passes, does it really make sense to back that crew in a road game against a perennial playoff contender?

Brock Purdy is back from injury but the 49ers may still lean heavily on Christian McCaffery. San Francisco is only averaging 16 points per game at home while also holding their opponents 15 points at home. The Jaguars have been inconsistent on offense, leaning more on Travis Etienne.

The 49ers will get QB Brock Purdy back, but I imagine he will be leaning on Christian McCaffrey and looking to get the ball out quick. The Niners cannot afford another big injury. Without WR Brandon Aiyuk & TE George Kittle, the 49ers are going to have to beat teams with their run game and defense. Losing star DE Nick Bosa doesn’t help, but I believe they can limit Jacksonville’s explosive plays. The Jaguars offense looks promising under Liam Coen, but they are still ironing out the kinks. Jags wideouts lead the league in drops, and Trevor Lawrence is still trying to establish chemistry with Brian Thomas Jr. Jacksonville’s defense looks much improved under DC Anthony Campanile. Play this Under at 46 or better.

New Jags HC Liam Coen is reportedly pleased with Trevor Lawrence's play, which has been hampered by dropsies from his receiving corps and some deflected passes that ended in the wrong hands. Meanwhile, the 49ers will get QB Brock Purdy, though still dealing with a toe injury, back for the first time since opening weee. Backup Mac Jones, however, is apparently out, so the Niners are getting thinned...again. Nick Bosa is now out for the season, and the old familiar 49ers receivers have a different look for the time being, with Deebo Samuel in Washington, while Brandon Aiyuk and George Kittle remain inactive. Keep in mind that Jacksonville is a few seconds away from a 3-0 start, and +3.5 definitely could be valuable. Play Jaguars

Two starting QBs who could not be more different. Jacksonville has prototype Trevor Lawrence, former No. 1 overall pick, one of the greatest recruits in sister-site 247Sports' history and basically Sunshine from Remember the Titans. San Fran has Mr. Irrelevant Brock Purdy, who probably worked at Pizza Hut (as did I so I don't hate), is basically Shane Falco and would have gotten pantsed/swirled if he was in the same locker room as Lawrence in high school. But things change don't they? With Purdy, who has been the better pro, cleared to return from injury, the Niners should escape at home.

The 49ers are undefeated, but they've won their three games by a total of 10 points. They just lost Nick Bosa to a season-ending knee injury. Brock Purdy might return from his turf toe injury, but even so he'll be dealing with a depleted receiver corps. The Jaguars lead the NFL with 13 dropped passes but have played well in other aspects. Jacksonville averages 5.1 yards per carry and has allowed three sacks through three games. Look for a tight game and grab the points.

Through three games Christian McCaffrey has been an absolute workhorse handling an absurd 77 touches (25 touches per game). While he’s still an elite football player he has been inefficient rushing the football averaging under 60 rushing yards per game on just 3.4 YPC. He will face a Jacksonville defense that is ranked 1st in Success Rate and has allowed just 185 rushing yards to RBs through 3 games, good for the 6th lowest mark in the league. I expect C-Mac to pile up plenty of scrimmage yards but this is a difficult matchup and this number feels inflated.

The 49ers were dealt a tough blow with Nick Bosa's injury, but they still have a quality edge rusher in Bryce Huff to lead the revitalized defense under Robert Saleh. The 49ers offense is getting more whole with Brock Purdy potentially back and Demarcus Robinson's suspension over. The Jaguars defense has had some easy home matchups and may struggle with an improving offense in a road matchup, while Trevor Lawrence has been responsible for some ugly picks as his top receivers have disappointed. This should be north of 3.