loading...
League Logo
NFL
League Logo
NFL
League Logo
CFB
League Logo
NBA
League Logo
CBB
League Logo
NHL
All
  • Loading...
loading...
Sun, Sep 215:00 pm UTCNissan Stadium
84 F
Indianapolis
Colts
IND
Last 5 ATS
W/L7-6
ATS8-5
O/U7-7-0
FINAL SCORE
41
-
20
Tennessee
Titans
TEN
Last 5 ATS
W/L3-11
ATS7-8
O/U9-6-0
SPREAD
MONEYLINE
OVER/UNDER
Last 5 ATS
7-6
Win /Loss
3-11
8-5
Spread
7-8
7-7-0
Over / Under
9-6-0
SPREAD
MONEYLINE
OVER/UNDER

Simulation Picks

SPREAD
IND @ TEN
Subscribers Only

Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks

MONEYLINE
IND @ TEN
Subscribers Only

Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks

OVER / UNDER
IND @ TEN
Subscribers Only

Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks

54%
PUBLIC
46%
MONEY
93%
PUBLIC
7%
MONEY
Over31%
PUBLIC
Under69%
Over
MONEY
Under

Understanding Public and Money

Think of 'Public' as the percentage of people betting on each side and 'Money' as how much money is being bet. When there's a big difference between the 'Public' and 'Money' data, it usually means that the more serious bettors (referred to as 'Sharp Money') are favoring a particular side.

Expert Picks

SpreadTennessee +6 -112
LOSS
Unit1.0
+195
149-138-5 in Last 292 NFL Picks
+80
3-2 in Last 5 NFL ATS Picks
+1018
28-16-3 in Last 47 IND ATS Picks
R.J.'s Analysis:

The Titans are dealing with major issues on the O-line as JC Latham and Kevin Zeitler are inactive, but I have to fade the Colts as six-point road favorites in a divisional matchup. Yes, the offense looked impressive against what is supposed to be a great Denver defense last week, but I have enough faith in this Tennessee defense to get stops. Cam Ward should also have a much easier time against this Colts defense than he did against the Broncos and Rams. Only a play if you can catch the six points.

Pick Made: Sep 21, 4:24 pm UTC on DraftKings
SpreadTennessee +5.5 -110
LOSS
Unit1.0
+265
5-2 in Last 7 NFL ATS Picks
Bob's Analysis:

Daniel Jones finally plays outdoors and are we sure that he’s going to continue his stellar play? Yes, the Titans have committed the most penalties in the league thus far, but the Colts have failed to cover their last six September games as road favorites. It’s seeming almost too easy to take Indianapolis here.

Pick Made: Sep 21, 3:10 pm UTC on DraftKings
Avatar
Longest ReceptionJosh Downs Under 17.5 Longest Reception -115
LOSS
Unit1.0
+1264
39-23 in Last 62 NFL Player Props Picks
Prop's Analysis:

DraftKings. Josh Downs is averaging 7.9 yards per reception this season, on a 7.3 average depth of target. While he did clear this line with a 19-yard catch last week, that was due to busted coverage, with a safety matched up on him. The fact is, the slot receiver is pretty low on the pecking order for deep targets, behind the likes of Michael Pittman, Alec Pierce and rookie standout, Tyler Warren. I’ll trust the Titans secondary here.

Pick Made: Sep 21, 2:30 pm UTC on DraftKings
Avatar
Anytime TD ScorerDaniel Jones Anytime Touchdown Scorer +185
LOSS
Unit1.0
+428
5-3 in Last 8 NFL Player Props Picks
Megan's Analysis:

"Indiana Jones", or Daniel Jones, has scored rushing touchdowns in the first two weeks (3 total) this season. Can he make it three weeks in a row? I think that's definitely in play. Remember, head coach Shane Steichen was the offensive coordinator with the Eagles when the "Tush Push" was born. While the Indy version with Jones is not the "Tush Push", but a standard quarterback sneak. The point is, Steichen obviously sees a value in using Jones and the quarterback sneak near the goal line. So getting nice plus odds at +185 feels like a value I want to play for Jones to score again in Week 3.

Pick Made: Sep 20, 8:29 pm UTC on FanDuel
SpreadTennessee +4.5 -115
LOSS
Unit1.0
+542.5
111-100-2 in Last 213 NFL Picks
Daniel's Analysis:

I’m selling high on the Colts after a dramatic win last week. The dome environment in Indy may be a key factor for Daniel Jones, who is 3-11 ATS in the last two seasons when playing outdoors. Now he heads to Tennessee to face an underrated Titans team, that had 2nd half leads over both the Rams & the Broncos. The Titans committed the most penalties through two weeks, and Cam Ward has been the most sacked quarterback… yet still Tennessee have been competitive in their first two games, despite what the box scores show. It looks like key Titans players RG Kevin Zeitler & CB L’Jarius Sneed will both play. I see this AFC South clash being decided by a field goal. Titan Up.

Pick Made: Sep 20, 12:49 pm UTC on DraftKings
Avatar
Rushing YardsTony Pollard Over 68.5 Total Rushing Yards -114
LOSS
Unit1.0
+388
19-13 in Last 32 NFL Player Props Picks
Sia's Analysis:

We went to this last week and it hit thanks to the anticipated volume that Pollard was to receive. He's looking at the same Rush Attempt number (17.5) against the Colts and I think he can hit this yardage number well before he reaches his 17th attempt. While Pollard hasn't been a model of efficiency, he's also gone up against two excellent defensive units in the Broncos and Rams. This week he gets a Colts defense far less impressive in a game that I expect to be relatively tight. The Titans only chance is to lean on Pollard.

Pick Made: Sep 19, 1:47 am UTC on FanDuel
Avatar
Receiving YardsTyler Warren Over 44.5 Total Receiving Yards -115
LOSS
Unit1.5
+1199
55-36 in Last 91 NFL Player Props Picks
Alex's Analysis:

As long as the oddsmakers continue to undervalue Tyler Warren we will continue to back the future All-Pro Tight End. I absolutely love the way that Tyler Warren is being utilized in a variety of ways as he is the clear focal point of the Colts revamped passing attack. Warren is the new RPO king and I’d make this his receiving line significantly higher considering his elite usage and receiving profile. Through the first two weeks of the season Warren leads all TEs in target share, air yards, YPRR, targets per route run, and virtually every key receiving metric.

Pick Made: Sep 18, 12:31 pm UTC on DraftKings

Team Injuries

Indianapolis Colts
Sunday, Dec 21, 2025
Avatar
OT
Bernhard Raimann
ElbowOut
Saturday, Dec 20, 2025
Avatar
CB
Sauce Gardner
CalfOut
Avatar
WR
Anthony Gould
FootOut
Tennessee Titans
Sunday, Dec 21, 2025
Avatar
SAF
Erick Hallett II
Coach's DecisionInactive
Avatar
CB
Marcus Harris
KneeQuestionable
Avatar
OT
Brandon Crenshaw-Dickson
Coach's DecisionInactive
Avatar
LB
Cedric Gray
ConcussionInactive
Avatar
DT
Cam Horsley
Coach's DecisionInactive
Avatar
G
Garrett Dellinger
Coach's DecisionInactive
Avatar
G
Drew Moss
Coach's DecisionInactive
© 2025 CBS INTERACTIVE INC. ALL RIGHTS RESERVED. SportsLine and SportsLine PRO are registered trademarks of SportsLine.com, Inc.FANS ONLY
In partnership with...247 Sports

FOLLOW US:

The content on this site is for entertainment purposes only and SportsLine makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event. There is no gambling offered on this site. This site contains commercial content and SportsLine may be compensated for the links provided on this site.