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Sun, Sep 075:00 pm UTCCaesars Superdome
Arizona
Cardinals
ARI
Last 5 ATS
W/L2-10
ATS6-7
O/U8-5-0
FINAL SCORE
20
-
13
New Orleans
Saints
NO
Last 5 ATS
W/L3-9
ATS5-8
O/U4-9-0
SPREAD
MONEYLINE
OVER/UNDER
Last 5 ATS
2-10
Win /Loss
3-9
6-7
Spread
5-8
8-5-0
Over / Under
4-9-0
SPREAD
MONEYLINE
OVER/UNDER

Simulation Picks

SPREAD
ARI @ NO
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Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks

MONEYLINE
ARI @ NO
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OVER / UNDER
ARI @ NO
Subscribers Only

Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks

37%
PUBLIC
63%
MONEY
93%
PUBLIC
7%
MONEY
Over22%
PUBLIC
Under78%
Over
MONEY
Under

Understanding Public and Money

Think of 'Public' as the percentage of people betting on each side and 'Money' as how much money is being bet. When there's a big difference between the 'Public' and 'Money' data, it usually means that the more serious bettors (referred to as 'Sharp Money') are favoring a particular side.

Expert Picks

Avatar
Anytime TD ScorerJames Conner Anytime Touchdown Scorer -160
WIN
Unit1.0
Megan's Analysis:

James Conner has the matchup and game script we love. The Cardinals are a big favorite and he has an excellent matchup vs. the Saints' rush defense. The Saints gave up 20 rushing touchdowns last season, tied for 5th most. They were also 30th in yards per carry to enemy backs last year. Even though the line is juiced, I love this Anytime Touchdown pick.

Pick Made: Sep 07, 1:58 am UTC on DraftKings
Avatar
Rushing YardsTrey Benson Over 25.5 Total Rushing Yards -114
WIN
Unit1.0
+729
27-17 in Last 44 NFL Player Props Picks
Prop's Analysis:

FanDuel. There’s been a ton of talk out of Cardinals camp of keeping 30-year old James Conner as fresh as possible, after a 2024 in which he set a career high with 283 touches. Enter second-year back Trey Benson, whom coaches have talked about getting more consistent touches this season. He should get the opportunity this week against the Saints. Not only should New Orleans struggle with ball control, but they’re also returning the league’s 30th ranked run defense in terms of DVOA (per FTN). Benson averaged 4.6 yards per rush attempt last season, and should be able to clear this line with just six totes. However, I have him in the seven-to-eight carry range on Sunday.

Pick Made: Sep 06, 1:50 pm UTC on FanDuel
Avatar
CarriesJames Conner Over 15.5 Total Carries -133
LOSS
Unit1.0
+980
11-2 in Last 13 NFL Player Props Picks
Dave's Analysis:

You can get 16.5 at plus money if you shop around but I don't mind laying the juice for one fewer carry. Conner had 17 or more carries in 8 of 13 games he played at least 47% of the snaps in last year, with the majority of those eight games Cardinals wins. Arizona's a favorite against a Saints defense that was the pits last year against the run and didn't do much to improve this year. I'm not worried about Trey Benson taking a ton of work, either. Conner should be a big part of Arizona's offense this week (and every week).

Pick Made: Sep 05, 3:47 pm UTC on BetRivers
Avatar
Receiving YardsRashid Shaheed Over 38.5 Total Receiving Yards -113
LOSS
Unit1.0
+98
15-12 in Last 27 NFL Player Props Picks
Sia's Analysis:

When Shaheed is healthy he's easily the WR2 and at times looks like the WR1 in this offense. That may not look super appealing in a Spencer Rattler led offense, but in a likely negative game script, I suspect he'll get plenty of looks. There's also some buzz that he'll be utilized more in the short area under the Kellen Moore administration. This has plenty of ladder potential.

Pick Made: Sep 05, 3:40 pm UTC on DraftKings
Avatar
Receiving YardsChris Olave Over 48.5 Total Receiving Yards -115
WIN
Unit2.0
+980
11-2 in Last 13 NFL Player Props Picks
Dave's Analysis:

Really love the idea of banking on Olave after a preseason full of him lining up everywhere in the Saints offense and being a primary target for Spencer Rattler. Olave didn't just have 51-plus yards last year, he had 81-plus yards in 4 of the 6 games he played at least 70% of the snaps in. Arizona's defense is improved, but the secondary still has a lot of questions.

Pick Made: Sep 05, 3:39 pm UTC on BetMGM
SpreadArizona -6.5 -104
WIN
Unit1.0
+466
8-3 in Last 11 NFL Picks
+276
5-2 in Last 7 NFL ATS Picks
Micah's Analysis:

I think the Saints will be a bad team this season, and it all starts with quarterbacks Spencer Rattler and Tyler Shough. And it really doesn't matter who they play in their home opener. That is the main point of this bet. I think the other team is going to do well against the Saints defense, which has a very underwhelming squad. It so happens that betting against the Saints has me on the Cardinals this week. On paper, the Cardinals look like they have the makings to be a quality playoff team. They have the offense set up perfectly for a special season. I had this game being a 31-10 type of score. Cardinals cover.

Pick Made: Sep 04, 8:03 pm UTC on FanDuel
Avatar
InterceptionsKyler Murray Over 0.5 Total Passing Interceptions -110
LOSS
Unit1.0
Stephen's Analysis:

Kyler Murray is averaging 0.72 INTs per sim which is roughly a 60% chance he throws at least one (our price -150). While he only threw an INT in 8 of 17 games last season (which explains the standard juice on over 0.5), he was much worse in the 2nd half of the season with INTs. He had zero in the first 2 weeks, 3 in the first 10 weeks before cratering with 8 in his final 7 games. The Saints may be the worst team in the league but they don't have the worst defense in the league. The Saints were a respectable 11th in the league with 14 interceptions last season.

Pick Made: Sep 04, 4:01 pm UTC on Caesars
Avatar
Rushing YardsTrey Benson Over 22.5 Total Rushing Yards -118
WIN
Unit1.0
+909
19-9 in Last 28 NFL Player Props Picks
R.J.'s Analysis:

This Over is lagging behind at this book compared to the rest of the market, but I expect everyone has it much too low. There are multiple ways to cashing here. Benson has impressed this summer and could be in line for more of an even split than last year, especially if Arizona wants to keep James Conner fresh for a potential playoff push. It's possible Benson averages 8-10 carries a week this season. Even if he's the clear No. 2, this Over could hit on mop-up duty in the second half. I'd play this up to 29.5 but I'm expecting closer to 50 yards for Benson here.

Pick Made: Sep 03, 12:08 pm UTC on BetMGM
SpreadArizona -5.5 -120
WIN
Unit1.0
+267
15-12 in Last 27 NFL ATS Picks
+290
4-1 in Last 5 NO ATS Picks
Jimmie's Analysis:

The Saints are rolling with Spencer Rattler as their starting QB for this game, and the former South Carolina standout left a lot to be desired with his play as a rookie in 2024. The Cardinals project to have an explosive offense, and an above average defense. New Orleans is a team that is very much in the Arch Manning race heading into the season, and I expect a comfortable Arizona win in Week 1.

Pick Made: Aug 27, 10:38 pm UTC on FanDuel

Team Injuries

Arizona Cardinals
Wednesday, Dec 10, 2025
Avatar
OT
Paris Johnson Jr.
Knee - MCLOut
Monday, Dec 08, 2025
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G
Evan Brown
PersonalQuestionable
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RB
Emari Demercado
AnkleQuestionable
Avatar
SAF
Dadrion Taylor-Demerson
AnkleQuestionable
Avatar
WR
Xavier Weaver
HamstringQuestionable
Avatar
CB
Max Melton
HeelQuestionable
Avatar
WR
Marvin Harrison Jr.
HeelQuestionable
Avatar
DT
Walter Nolen
KneeQuestionable
Sunday, Dec 07, 2025
Avatar
DT
Bilal Nichols
KneeQuestionable
New Orleans Saints
Wednesday, Dec 10, 2025
Avatar
DE
Chris Rumph II
WristQuestionable
Avatar
RB
Devin Neal
AbdomenQuestionable
Monday, Dec 08, 2025
Avatar
RB
Alvin Kamara
Knee - MCLQuestionable
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S
Justin Reid
KneeQuestionable
Avatar
OT
Asim Richards
AnkleQuestionable
Avatar
OT
Taliese Fuaga
AnkleQuestionable
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