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Sun, Jan 059:25 pm UTCState Farm Stadium
San Francisco
49ers
SF
Last 5 ATS
W/L6-11
ATS5-12
O/U9-8-0
FINAL SCORE
24
-
47
Arizona
Cardinals
ARI
Last 5 ATS
W/L8-9
ATS11-6
O/U8-7-2
SPREAD
MONEYLINE
OVER/UNDER
Last 5 ATS
6-11
Win /Loss
8-9
5-12
Spread
11-6
9-8-0
Over / Under
8-7-2
SPREAD
MONEYLINE
OVER/UNDER

Simulation Picks

SPREAD
SF @ ARI
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MONEYLINE
SF @ ARI
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OVER / UNDER
SF @ ARI
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59%
PUBLIC
41%
MONEY
26%
PUBLIC
74%
MONEY
Over87%
PUBLIC
Under13%
Over
MONEY
Under

Understanding Public and Money

Think of 'Public' as the percentage of people betting on each side and 'Money' as how much money is being bet. When there's a big difference between the 'Public' and 'Money' data, it usually means that the more serious bettors (referred to as 'Sharp Money') are favoring a particular side.

Expert Picks

Avatar
Anytime Touchdown ScorerTrey McBride Anytime Touchdown Scorer +155
WIN
Unit1.0
+15
4-4 in Last 8 NFL Player Props Picks
Jason's Analysis:

So we waiting all season for this to finally hit, after he dominated the targets and paced the passing game all season. And now the pressure if off Kyler Murray and I suspect he feeds his favorite target and we get better value here than in most markets before McBride finally caught a TD. Things don't seem rosy between Murray and Marvin Harrison JR. 49ers short on LBs and McBride saw 9 targets in last meeting when a reserve TE caught a TD pass. McBride has 104 receptions and no one else on the team has 58. Overdue for more TDs and facing wounded opponent.

Pick Made: Jan 05, 5:35 pm UTC on FanDuel
Avatar
Total Rushing YardsMichael Carter Over 56.5 Total Rushing Yards -115
LOSS
Unit1.0
+348
152-122 in Last 274 NFL Player Props Picks
Larry's Analysis:

James Connor, Trey Benson and Emari Demercado are out, meaning it will be the Michael Carter show for Arizona. He looked good last week against the Rams, rushing 13 times for 70 yards. The 2021 fourth-round pick will face a 49ers team that ranks 28th in rushing efficiency defense.

Pick Made: Jan 05, 4:49 am UTC on BetMGM
Avatar
Anytime Touchdown ScorerKyler Murray Anytime Touchdown Scorer +100
LOSS
Unit1.0
+577.25
36-31 in Last 67 NFL Player Props Picks
Megan's Analysis:

Kyler Murray needs 50+ rushing yards and one rushing touchdown to hit a contract incentive that would pay $750,000. Murray can call his own number and not have to rely on others to achieve this bonus. Murray had 83 rushing yards and a rushing touchdown the first time these teams met earlier in the season. I like Murray to find the endzone in the season finale to get his bonus.

Pick Made: Jan 04, 11:53 pm UTC on Caesars
Point SpreadArizona -4.5 -110
WIN
Unit1.0
+853
53-40-2 in Last 95 NFL ATS Picks
+1360
18-4 in Last 22 SF ATS Picks
Micah's Analysis:

The 49ers have lost six of their last seven games and are mailing the season in as their quarterback will be Joshua Dobbs and backups for starters Deebo Samuel, George Kittle, and Nick Bosa are expected. The Cardinals beat the 49ers earlier in the year and they'll be without RB James Conner but Kyler Murray will start. The Cardinals went 10-6 against the spread and Murray needs to earn the city back after not making the playoffs. Murray gets the win with compliments of Trey McBride and Marvin Harrison Jr.

Pick Made: Jan 04, 12:59 am UTC on Caesars
Point SpreadArizona -4 -108
WIN
Unit1.0
+2007
61-37-3 in Last 101 NFL ATS Picks
Mike's Analysis:

The 49ers have endured an epidemic of injuries, capped by QB Brock Purdy's bum elbow suffered on Monday night that ends his season. The defense was lacerated by Detroit, and the offense is missing a roll call of contributors. San Fran is staggering to the finish line in a short week. The Cardinals have been up-and-down -- mostly down in recent weeks -- but should be motivated to complete a season sweep of a division foe that historically dominates them. 'Zona scored a one-point win in the Bay Area in Week Six.

Pick Made: Dec 31, 8:53 pm UTC on DraftKings
Money LineArizona -149
WIN
Unit1.5
+1938
37-12 in Last 49 NFL ML Picks
Matt's Analysis:

This feels like the classic case of a coach trying to build something -- Arizona's Jonathan Gannon -- who will play all his healthy starters against one who may not -- SF's Kyle Shanahan after so many extra playoff games the past few years. Short week for the Niners, anyways, and Brock Purdy probably is out for legit reasons after hurting his elbow on Monday night. I rather doubt most key 49ers play in this meaningless one.

Pick Made: Dec 31, 1:27 pm UTC on BetMGM

Team Injuries

San Francisco 49ers
Monday, Dec 01, 2025
Avatar
K
Eddy Pineiro
HamstringQuestionable
Avatar
LB
Tatum Bethune
AnkleQuestionable
Avatar
DT
Sam Okuayinonu
AnkleQuestionable
Avatar
OT
Ben Bartch
FootOut
Sunday, Nov 30, 2025
Avatar
FB
Kyle Juszczyk
RibsQuestionable
Avatar
LB
Nick Martin
ConcussionQuestionable
Arizona Cardinals
Thursday, Dec 04, 2025
Avatar
WR
Xavier Weaver
HamstringQuestionable
Wednesday, Dec 03, 2025
Avatar
OT
Kelvin Beachum
GroinQuestionable
Avatar
WR
Greg Dortch
ChestQuestionable
Monday, Dec 01, 2025
Avatar
RB
Emari Demercado
AnkleQuestionable
Avatar
SAF
Dadrion Taylor-Demerson
AnkleQuestionable
Avatar
CB
Max Melton
HeelQuestionable
Avatar
WR
Marvin Harrison Jr.
HeelQuestionable
Avatar
DT
Walter Nolen
KneeQuestionable
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