ANALYSIS: Will the Jaguars continue to surprise when they play the... Join SportsLine here to see the full pick!

ANALYSIS: Will the Lions keep covering the spread despite a rash of... Join SportsLine here to see the full pick!

ANALYSIS: What is it that the Seahawks do well? They can't run the ball (fewest rush yards in the league), can't pass much (2 TDs, 2 INTs, sixth fewest yards), they're bottom 10 in both pass and run defense, and they're without Jamal Adams. Somehow they won a game, but even with this one in Seattle against a winless Falcons team, it feels like the wrong side is favored. The Falcons are 2-0 ATS, and they haven't even gotten Kyle Pitts involved yet. Grab the point.

ANALYSIS: With Jimmy Garoppolo as starter, the 49ers got to the NFC title game last year and the Super Bowl two years prior. Granted, he was far from the main reason they made it that far -- but the Niners know who they are now, something they didn't know with Trey Lance. I think we see a more confident Niners team with Jimmy G and George Kittle both back in the fold. Maybe Russell Wilson steps up his play a bit in the primetime lights, but the Niners are the more talented team with the better coach, and have some comfort back on offense. Lay the point and a half.

ANALYSIS: The Vikings looked great against the Packers in Week 1, but what happens when they face a team that has some good receivers? On the road? In front of a rowdy Philly crowd in its home opener? With Kirk Cousins playing in primetime (career record: 8-17)? The line implies that these teams are even, but I think overall the Eagles are a bit more talented, and that edge will be magnified on 'MNF.' Lay the points.