ANALYSIS: Maybe the Saints won't miss the army of assistant coaches who'll be out this week due to COVID protocol. But Erik McCoy? Kwon Alexander? Marcus Davenport? They'll be missed, and Marshon Lattimore is questionable as well. The Panthers are feisty under Matt Rhule, and getting more than a field goal for a divisional game in Carolina feels inflated due to the Saints' Week 1 romp. Grab the points.

ANALYSIS: You never want to overreact to Week 1, but the Jags defense allowed 31 points per game last season and managed to top that by giving up 37 to the Tyrod Taylor-led Texans. Urban Meyer is (unconvincingly) denying interest in returning to college after just one NFL game, and I don't want to bet on his team against anyone at less than a touchdown -- especially with Teddy Covers and a good Broncos defense coming to town. Lay the points.

ANALYSIS: You could say the Dolphins got lucky in Week 1 due to a late Pats fumble ... or you could say the Dolphins impressively won on Bill Belichick's home turf and their rising defense forced a crucial turnover. I see it as the latter. Everything went almost perfectly for the 13-3 Bills of 2020, and even then they didn't beat the Fins by more than a field goal in hot and humid Florida. Fade the public (70% of bets are on the Bills) and grab the points.

ANALYSIS: Zach Wilson was impressive in the preseason, but that's the preseason. The rookie QB will be start the regular season on the road with a banged-up receiving corps and a bad offensive line, while leaning on a rookie head coach for advice. Are we sure Sam Darnold's biggest issue wasn't Adam Gase? Lay the 3.5.

ANALYSIS: The Colts have the better defense here, and they're getting points at home. But how does Carson Wentz -- the same Wentz who was the worst starting QB in the league last season -- suddenly look good again despite missing three weeks of practice with a foot injury and additional time on the COViD list? Maybe Frank Reich works his magic and gets Wentz going, but it's hard to imagine it happening now (and with the Colts missing both their 2020 leading receiver and starting left tackle). Ride with Russell Wilson and lay the points.