Although we don't know how long Tua's physical health or Tyreek's mental health will hold up, and coach Mime McDaniel could easily cash his short odds for first coach to be fired, this is till a good spot for the Dolphins. They're healthy for now and the Colts don't won't be able to expose their weak secondary as often as other opponents will.

With this game being indoors on turf, you have to like the speed and explosiveness of the entire Dolphins team. When you look at the Dolphins defensive edge rushers going up against a QB in Daniel Jones who struggles to get rid of the ball, it's a matchup that you can trust in terms of locking down a road win for Miami.

The Miami Dolphins have become extremely predictable under Mike McDaniels' time-based offensive scheme. I heard opposing defenses call out Miami's plays pre-snap last year. I have the Dolphins under and the Colts over in season win totals. Daniel Jones is an upgrade over Anthony Richardson. Miami will be without its Pro Bowl kicker, Jason Sanders, who made 12 of 15 beyond 50 yards last year. The Colts should be motivated as they have a record of 0-4-1 straight up in Week One over the last five years.

FanDuel. Jonathan Taylor has a nice matchup to kick off his 2025 campaign. The sixth-year back will face off against the Dolphins, who once again profile as below average against the run (after ranking 22nd in FTN Fantasy’s DVOA metric last year. Taylor averaged over 100 yards per game on the ground in 2024, clearing this line in ten of fourteen games. With this being a make-or-break year for the Colts coaching staff, I see them giving their workhorse as much volume as he can handle, in a very winnable Week 1 matchup. I’d bet this line up to over 83.5 rushing yards.

This line is down to a pick 'em at some spots, which seems unfair to a Colts team that has played to a .500 record the last two years despite poor options at QB. The Dolphins defense has been a work in progress throughout the summer with cornerback specifically a turnstile due to injuries and recent signings. I expect it's going to take the Miami defense time to find a rhythm, while the offense has been managing injuries to key players and even the kicking game is suspect with Jason Sanders out. Indy should be favored, so I like grabbing a -110 money line here.