ANALYSIS: Both teams are looking for bounce-back efforts here in a tough spot as competing top-tier units are going against one another. The 49ers are getting some key defensive reinforcements back, while the Chiefs are making a much-needed change at running back that should help their offense find more consistency. San Francisco is garnering a lot of love early this season, but for what, exactly? Beating up on Carolina and Seattle? Losing to Chicago, Denver and Atlanta? The Chiefs have been tested frequently through the first third of the season and have the quarterback I trust more to pull out a win late in Patrick Mahomes.