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    Sat, Dec 269:30 pm UTCState Farm Stadium
    68 F
    Track OnCBS Sports
    San Francisco
    49ers
    SF
    Last 5 ATS
    W/L6-10
    ATS7-9
    O/U8-8-0
    FINAL SCORE
    --
    -
    --
    Arizona
    Cardinals
    ARI
    Last 5 ATS
    W/L8-8
    ATS7-9
    O/U5-11-0
    SPREAD
    MONEYLINE
    OVER/UNDER
    Last 5 ATS
    6-10
    Win /Loss
    8-8
    7-9
    Spread
    7-9
    8-8-0
    Over / Under
    5-11-0
    Key Injuries
    Key Injuries
    Avatar
    DE
    Avatar
    NT
    Avatar
    DE
    Key Injuries
    Avatar
    DE
    Avatar
    C
    Avatar
    OT
    SPREAD
    MONEYLINE
    OVER/UNDER

    Simulation Picks

    SPREAD
    SF @ ARI
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    MONEYLINE
    SF @ ARI
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    OVER / UNDER
    SF @ ARI
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    0%
    PUBLIC
    0%
    MONEY
    0%
    PUBLIC
    0%
    MONEY
    Over0%
    PUBLIC
    Under0%
    Over
    MONEY
    Under

    Expert Picks

    Point SpreadArizona -6.5 -110
    LOSS
    Unit1.0
    +280
    25-20-2 in Last 47 NFL Picks
    Mike's Analysis:

    The 49ers have not played in their stadium since Nov. 5 after relocating to Phoenix, and the extended time away from home surely is wearing on them. They are down to quarterback No. 3, C.J. Beathard, whose straight-up record as a starter is 1-9. The Niners, overwhelmed by injuries, have won once outright in the past seven games with superior QBs. With 14 sacks in the last two weeks, ravenous Cardinals pass rushers will have Beathard on his heels.

    Pick Made: Dec 26, 7:17 pm UTC
    Point SpreadArizona -5.5 -112
    LOSS
    Unit1.0
    +476
    8-3-1 in Last 12 SF ATS Picks
    Adam's Analysis:

    This is on its way to a full touchdown, but I'm still comfortable picking the Cardinals. Kyle Murray is undefeated ATS (2-0-1) against the 49ers, and this San Francisco team is going to have trouble scoring. Even Arizona coach Kliff Kingsbury won't throw this one away. The Cards have won consecutive games ATS, while the 49ers are on an 0-3 ATS streak. Forget the quarterback change in San Francisco, it is down significant playmaking talent as well.

    Pick Made: Dec 26, 4:57 pm UTC
    Point SpreadArizona -4.5 -110
    LOSS
    Unit1.0
    +1495
    82-60-5 in Last 147 NFL Picks
    +1160
    60-43-5 in Last 108 NFL ATS Picks
    +910
    38-28 in Last 66 SF ATS Picks
    R.J.'s Analysis:

    I typically wouldn't be looking to lay this many points in a divisional matchup like this, but I just don't see the 49ers having much success on either side of the ball with their numerous injuries. Yes, George Kittle is on the way back, but that's more than outweighed by losing Nick Mullens, Deebo Samuel, Raheem Mostert and Richard Sherman. A healthy Kyler Murray should have success against a banged-up 49ers defense, while the Cardinals' ninth-ranked DVOA defense is good enough to limit what C.J. Beathard can do. I think this line should be Cardinals -6.5 or -7 due to the San Francisco injury report, so this is some nice value in the matchup.

    Pick Made: Dec 25, 8:26 pm UTC
    Point SpreadArizona -5 -110
    LOSS
    Unit1.0
    +725
    22-13-2 in Last 37 NFL ATS Picks
    +270
    5-2-1 in Last 8 ARI ATS Picks
    Larry's Analysis:

    The Cardinals are 5-0-1 ATS in the last six meetings, and that should continue Saturday against the C.J. Beathard-led 49ers. Arizona has 14 sacks the past two weeks, and should force Beathard into mistakes. Deebo Samuel remains out, and George Kittle isn't going to play a full complement of snaps. Lay it.

    Pick Made: Dec 25, 3:44 am UTC
    Point SpreadArizona -5 -110
    LOSS
    Unit1.0
    +490
    25-18-4 in Last 47 NFL Picks
    Hank's Analysis:

    The 49ers just gave up 41 points to the Cowboys, and now they have to deal with Kyler Murray. With C.J. Beathard slated to start for San Fran, back the Cardinals to win and cover.

    Pick Made: Dec 23, 4:48 am UTC
    Point SpreadArizona -4.5 -110
    LOSS
    Unit1.0
    +35
    2-1 in Last 3 NFL Picks
    +310
    11-7 in Last 18 SF ATS Picks
    Matt's Analysis:

    News just came down that Niners QB Nick Mullens is expected out with an elbow injury and that third-string QB Josh Johnson landed on the reserve/COVID-19 list. He would’ve been promoted. That means it presumably will be CJ Beathard here as I can't imagine a scenario where the nothing-to-play for 49ers try to put Jimmy Garoppolo back out there. Arizona, meanwhile, can clinch a playoff spot with a win and some help on Sunday. This doesn't seem like it will be very close -- San Francisco as it is has failed to cover six straight in the series.

    Pick Made: Dec 22, 7:19 pm UTC

    Team Injuries

    San Francisco 49ers
    Thursday, Feb 22, 2024
    Avatar
    CB
    Charvarius Ward
    UndisclosedQuestionable
    Tuesday, Feb 13, 2024
    Avatar
    DE
    Arik Armstead
    Knee - MeniscusQuestionable
    Avatar
    NT
    Javon Hargrave
    ThumbQuestionable
    Avatar
    DE
    Clelin Ferrell
    KneeQuestionable
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    DT
    Kalia Davis
    AnkleQuestionable
    Avatar
    OT
    Nick Zakelj
    BicepsQuestionable
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    TE
    Ross Dwelley
    AnkleQuestionable
    Avatar
    SS
    Talanoa Hufanga
    Knee - ACLQuestionable
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    TE
    Cameron Latu
    Knee - MeniscusQuestionable
    Avatar
    DE
    Drake Jackson
    KneeQuestionable
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    WR
    Danny Gray
    Shoulder - AC JointQuestionable
    Monday, Feb 12, 2024
    Avatar
    LB
    Dre Greenlaw
    AchillesQuestionable
    Arizona Cardinals
    Monday, Feb 12, 2024
    Avatar
    DE
    Carlos Watkins
    BicepsQuestionable
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    C
    Pat Elflein
    UndisclosedQuestionable
    Avatar
    OT
    D.J. Humphries
    Knee - ACLQuestionable
    Avatar
    DE
    L.J. Collier
    BicepsQuestionable
    Avatar
    RB
    Marlon Mack
    AchillesQuestionable
    Avatar
    TE
    Geoff Swaim
    CalfQuestionable
    Avatar
    DE
    Jonathan Ledbetter
    KneeQuestionable
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    CB
    Rashad Fenton
    UndisclosedQuestionable
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    ILB
    Kyzir White
    ElbowQuestionable
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    WR
    Marquise Brown
    HeelQuestionable
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    LS
    Matt Hembrough
    BackQuestionable
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    LB
    Josh Woods
    AbdomenQuestionable
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    OG
    Jon Gaines II
    KneeQuestionable
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    DT
    Dante Stills
    KneeQuestionable
    Friday, Jan 19, 2024
    Avatar
    CB
    Garrett Williams
    AnkleQuestionable