ANALYSIS: Home-field advantage has ebbed in the NFL, but it stays relevant in Seattle. Since QB Russell Wilson arrived, the Seahawks have won 77 percent straight-up in their building. They have covered six of the last nine overall at home and are on a 5-0 ATS streak in September games. The Titans’ defense allowed 38 points to Arizona in the first three quarters before the Cardinals packed it in. Tennessee's vaunted offense stumbled badly out of the blocks, too, with Ryan Tannehill suffering six sacks and RB Derrick Henry kept in check.

ANALYSIS: Driven from home by Hurricane Ida, the Saints are now dealing with multiple absentees — primarily from the sideline. COVID-19 protocols will keep seven assistant coaches out of the stadium. Five players are ruled out for a more conventional reason -- injuries -- with DE Marcus Davenport and C Erik McCoy leaving big holes to fill. Ailing standout CB Marshon Lattimore is a game-time call. That’s lots of disruption to overcome. QB Sam Darnold should be more comfortable in his second start with Carolina. The Panthers have covered in eight of the last 10 as underdogs.

ANALYSIS: Judging from this healthy spread, the public considers Houston’s convincing win over Jacksonville a fluke. Well, which QB has covered in his last six starts? Answer: The Texans’ Tyrod Taylor. Conversely, which QB has covered in four of his past dozen? Answer: Cleveland’s Baker Mayfield. The Browns may be poised for a Super Bowl run but have no business yielding nearly two touchdowns worth of points. Houston’s 37 points against the Jaguars were legit, with 449 yards piled up.

ANALYSIS: Let’s ride the Matthew Stafford train for awhile. His Rams debut met all expectations, affirming L.A. as the second pick to win the NFC. Coach Sean McVay thrives early in the season (plus-five ATS in September) and away from home (plus-six ATS). Unlike Stafford, Colts QB Carson Wentz was mediocre in his debut with a new team. His coach, Frank Reich, has yet to pull off an ATS win at home when receiving points, and the Indy secondary is overmatched against the Stafford-led pass attack.

ANALYSIS: Jaguars rookie QB Trevor Lawrence endured a harsh initiation into the league, and he ain’t seen nothing yet. Relentless pass rusher Von Miller, sidelined throughout 2020 with an injury, launched his return with two sacks against the Giants. Denver will dial up blitzes for Miller and sidekicks to confound Lawrence. The Broncos’ limited offense took a hit with an injury to primary WR Jerry Jeudy, who caught six passes in New York before going down. These signs point to a low score.