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nfl - Tue 12/08 | 1:15 AM UTC | State Farm Stadium |

Buffalo @ San Francisco

Odds by William Hill Sportsbook
ATS
BUF -2.5
-2.5
Over / Under
48
48
ML
BUF -145
-160

Matchup breakdown

Buffalo
SF
PROJ SCORE
14-3
W-L
6-9
11-6
ATS W-L
6-9
11-4
O/U
7-7
7.6
PT DIFF
-0.7
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Past Expert Picks

Larry Hartstein

Senior Analyst
Fri 12/4

Buffalo @ San Francisco | 12/08 | 1:15 AM UTC

San Francisco PK

LOSS

Monday will mark the third time Deebo Samuel, Raheem Mostert and Brandon Aiyuk are on the field together. The presence of those outside threats can only help Mostert and the 49ers' running game. Buffalo gives up 4.7 yards per carry; only seven teams are worse. John Brown's absence takes the Bills' offense down a notch. Play on the desperate, improving 49ers.

+890 19-9-2 IN LAST 30 NFL ATS PICKS

Stephen Oh

Data Scientist
Sun 12/6

Buffalo @ San Francisco | 12/08 | 1:15 AM UTC

Buffalo +1

WIN

The Bills rushing game got off to a slow start this season but seems to be picking up steam recently with 126 rushing yards in three of their last five games, and one of those Unders came when they decided to almost exclusively pass the ball. My model says Buffalo covers more than 50 percent of the time -- and wins 26-23 -- so you're getting good value with the Bills at this number.

+400 4-0 IN LAST 4 SF ATS PICKS
+185 3-1 IN LAST 4 BUF ATS PICKS

R.J. White

Super Stat Geek
Fri 12/4

Buffalo @ San Francisco | 12/08 | 1:15 AM UTC

Buffalo +1

WIN

This line has steamed to the 49ers, but I'm not sure I understand why. Yes, the 49ers got healthier during their Week 11 bye and their defense showed up against a good offense from Los Angeles. But you can say the exact same thing about the Bills, who allowed their lowest point total in a non-Jets game (important qualifier) all season against the Chargers. The 49ers offense, which is still without its quarterback and best overall player, has turned the ball over multiple times in five straight games, and the Bills defense ranks fourth in the league in turnover rate. Now we get to the fact that it's a neutral field game where we're getting a point with the better team. Love the Bills here.

+1670 78-55-5 IN LAST 138 NFL PICKS
+475 19-13 IN LAST 32 SF ATS PICKS

Tom Fornelli

#TrustTheProcess
Wed 12/2

Buffalo @ San Francisco | 12/08 | 1:15 AM UTC

San Francisco +2.5

LOSS

We're dealing with an unusual situation here, as this 49ers "home" game will be played in Arizona, but with so few fans allowed in attendance at games this season, I'm not sure that has any actual impact. Which is why I like the 49ers as home dogs in this spot. Buffalo is a good team, but I'm not quite ready to trust the Bills as road favorites against a team that's not entirely incompetent, and the 49ers, for their faults, are not entirely incompetent.

+85 3-2-2 IN LAST 7 NFL ATS PICKS
+551 12-6 IN LAST 18 SF ATS PICKS
+95 2-1-1 IN LAST 4 BUF ATS PICKS

Hank Goldberg

Hammer
Wed 12/2

Buffalo @ San Francisco | 12/08 | 1:15 AM UTC

San Francisco +2.5

LOSS

The 49ers don't have a home but they're getting healthier. Richard Sherman, Deebo Samuel and Raheem Mostert make a big difference. Nick Mullens played well last week and Buffalo's defense doesn't thrill me. Kyle Shanahan is doing a heckuva coaching job. Grab the points.

+535 23-16-4 IN LAST 43 NFL ATS PICKS
+723 15-7-2 IN LAST 24 BUF ATS PICKS

Matt Severance

Severance Pays
Mon 12/7

Buffalo @ San Francisco | 12/08 | 1:15 AM UTC

Buffalo +1

WIN

That the Niners are short favorites is a bit surprising considering it's not a true home game but at a neutral site in Arizona -- and the Bills are familiar with playing there, losing on a Hail Murray in Week 10. If Jimmy Garoppolo and George Kittle were healthy, I would lean San Francisco but not with Nick Mullens under center. Plus, the Bills are arguably the healthiest they have been all season with nary a player even listed as questionable. Starting linebacker Matt Milano could be activated off IR today and return as well. He was at practice last week. Buffalo has just one ATS loss in its past nine as a road dog.

+225 20-16-1 IN LAST 37 NFL PICKS
+190 3-1 IN LAST 4 SF ATS PICKS

Buffalo

player
QBJoshAllen
19.47fan duel
20.43draft kings
21.57cbs sports
player
RBDevinSingletary
8.61fan duel
10.13draft kings
7.66cbs sports
player
RBZackMoss
7.48fan duel
8.22draft kings
7.13cbs sports
PASSINGCP/ATTYDTDINTFUMLFP
J. AllenJosh Allen22/352371.601.100.2821.6
RUSHINGRUSHYDTDYPCFUMLFP
D. SingletaryDevin Singletary10.8510.224.70.137.7
Z. MossZack Moss9.9420.364.30.117.1
J. AllenJosh Allen5.4250.384.70.2821.6
RECEIVINGRECYDTDYPRFUMLFP
S. DiggsStefon Diggs6.4760.3811.90.0710.1
C. BeasleyCole Beasley5.3590.3211.20.057.8
G. DavisGabriel Davis2.1330.3115.70.025.2
D. KnoxDawson Knox1.6200.1412.70.112.7
I. McKenzieIsaiah McKenzie2.2190.178.60.043.3
D. SingletaryDevin Singletary1.9140.027.30.137.7
DEF-STSACKINTFRECFGMFGAXP
B. DSTBUF DST2.771.371.041.71.92.4

PLAYERS LISTED AS OUT OR DOUBTFUL:

John Brown, Tyler Kroft, T.J. Yeldon, Tommy Sweeney, E.J. Gaines, Trent Murphy, Star Lotulelei, Isaiah Hodgins, Jake Fromm, Del`Shawn Phillips
*Questionable players are included in the projection.

San Francisco

player
QBNickMullens
13.16fan duel$6,700
13.76draft kings$5,100
14.66cbs sports
player
RBRaheemMostert
11.01fan duel$7,100
12.54draft kings$6,200
10.11cbs sports
player
RBJeffWilson
5.68fan duel$5,200
6.09draft kings$4,000
5.44cbs sports
PASSINGCP/ATTYDTDINTFUMLFP
N. MullensNick Mullens20/292161.401.300.2314.7
RUSHINGRUSHYDTDYPCFUMLFP
R. MostertRaheem Mostert10.0520.445.20.1510.1
J. WilsonJeff Wilson7.3280.313.80.145.4
J. McKinnonJerick McKinnon5.9260.254.30.095.9
RECEIVINGRECYDTDYPRFUMLFP
D. SamuelDeebo Samuel5.2610.2611.70.068.4
B. AiyukBrandon Aiyuk4.1510.3712.50.058.2
R. JamesRichie James1.8300.1816.80.113.9
J. ReedJordan Reed3.0270.319.00.034.6
K. BourneKendrick Bourne2.0230.1311.50.023.1
R. MostertRaheem Mostert1.8180.1110.10.1510.1
DEF-STSACKINTFRECFGMFGAXP
S. DSTSF DST2.461.171.001.51.72.4

PLAYERS LISTED AS OUT OR DOUBTFUL:

Jimmy Garoppolo, George Kittle, Trent Taylor, JaMycal Hasty, Emmanuel Moseley, Jaquiski Tartt, J.J. Nelson, Nick Bosa, Travis Benjamin, Kiko Alonso, K`Waun Williams, Dee Ford, Ronald Blair, Jamar Taylor, Solomon Thomas, Ezekiel Ansah, Ken Webster, Jalen Hurd
*Questionable players are included in the projection.

last updated: 12/08/2020 00:03 GMT