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    Tue, Dec 081:15 am UTCState Farm Stadium
    62 F
    Track OnCBS Sports
    Buffalo
    Bills
    BUF
    Last 5 ATS
    W/L13-3
    ATS11-5
    O/U11-4-1
    FINAL SCORE
    --
    -
    --
    San Francisco
    49ers
    SF
    Last 5 ATS
    W/L6-10
    ATS7-9
    O/U8-8-0
    SPREAD
    MONEYLINE
    OVER/UNDER
    Last 5 ATS
    13-3
    Win /Loss
    6-10
    11-5
    Spread
    7-9
    11-4-1
    Over / Under
    8-8-0
    Key Injuries
    Key Injuries
    Avatar
    OLB
    Avatar
    OT
    Avatar
    SAF
    Key Injuries
    Avatar
    NT
    Avatar
    LB
    Avatar
    SAF
    SPREAD
    MONEYLINE
    OVER/UNDER

    Simulation Picks

    SPREAD
    BUF @ SF
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    MONEYLINE
    BUF @ SF
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    OVER / UNDER
    BUF @ SF
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    0%
    PUBLIC
    0%
    MONEY
    0%
    PUBLIC
    0%
    MONEY
    Over0%
    PUBLIC
    Under0%
    Over
    MONEY
    Under

    Expert Picks

    Point SpreadBuffalo +1 -110
    WIN
    Unit1.0
    +35
    2-1 in Last 3 NFL Picks
    +310
    11-7 in Last 18 SF ATS Picks
    Matt's Analysis:

    That the Niners are short favorites is a bit surprising considering it's not a true home game but at a neutral site in Arizona -- and the Bills are familiar with playing there, losing on a Hail Murray in Week 10. If Jimmy Garoppolo and George Kittle were healthy, I would lean San Francisco but not with Nick Mullens under center. Plus, the Bills are arguably the healthiest they have been all season with nary a player even listed as questionable. Starting linebacker Matt Milano could be activated off IR today and return as well. He was at practice last week. Buffalo has just one ATS loss in its past nine as a road dog.

    Pick Made: Dec 07, 2:55 pm UTC
    Point SpreadBuffalo +1 -110
    WIN
    Unit1.0
    +400
    4-0 in Last 4 SF ATS Picks
    Stephen's Analysis:

    The Bills rushing game got off to a slow start this season but seems to be picking up steam recently with 126 rushing yards in three of their last five games, and one of those Unders came when they decided to almost exclusively pass the ball. My model says Buffalo covers more than 50 percent of the time -- and wins 26-23 -- so you're getting good value with the Bills at this number.

    Pick Made: Dec 06, 12:29 am UTC
    Point SpreadBuffalo +1 -115
    WIN
    Unit1.0
    +1495
    82-60-5 in Last 147 NFL Picks
    +1160
    60-43-5 in Last 108 NFL ATS Picks
    +910
    38-28 in Last 66 SF ATS Picks
    R.J.'s Analysis:

    This line has steamed to the 49ers, but I'm not sure I understand why. Yes, the 49ers got healthier during their Week 11 bye and their defense showed up against a good offense from Los Angeles. But you can say the exact same thing about the Bills, who allowed their lowest point total in a non-Jets game (important qualifier) all season against the Chargers. The 49ers offense, which is still without its quarterback and best overall player, has turned the ball over multiple times in five straight games, and the Bills defense ranks fourth in the league in turnover rate. Now we get to the fact that it's a neutral field game where we're getting a point with the better team. Love the Bills here.

    Pick Made: Dec 04, 9:54 pm UTC
    Point SpreadSan Francisco PK -110
    LOSS
    Unit1.0
    +725
    22-13-2 in Last 37 NFL ATS Picks
    +1050
    16-5-1 in Last 22 BUF ATS Picks
    Larry's Analysis:

    Monday will mark the third time Deebo Samuel, Raheem Mostert and Brandon Aiyuk are on the field together. The presence of those outside threats can only help Mostert and the 49ers' running game. Buffalo gives up 4.7 yards per carry; only seven teams are worse. John Brown's absence takes the Bills' offense down a notch. Play on the desperate, improving 49ers.

    Pick Made: Dec 04, 3:01 am UTC
    Point SpreadSan Francisco +2.5 -105
    LOSS
    Unit1.0
    +175
    5-3-2 in Last 10 NFL Picks
    +85
    3-2-2 in Last 7 NFL ATS Picks
    +741
    15-7 in Last 22 SF ATS Picks
    Tom's Analysis:

    We're dealing with an unusual situation here, as this 49ers "home" game will be played in Arizona, but with so few fans allowed in attendance at games this season, I'm not sure that has any actual impact. Which is why I like the 49ers as home dogs in this spot. Buffalo is a good team, but I'm not quite ready to trust the Bills as road favorites against a team that's not entirely incompetent, and the 49ers, for their faults, are not entirely incompetent.

    Pick Made: Dec 02, 7:18 pm UTC
    Point SpreadSan Francisco +2.5 -105
    LOSS
    Unit1.0
    +490
    25-18-4 in Last 47 NFL Picks
    Hank's Analysis:

    The 49ers don't have a home but they're getting healthier. Richard Sherman, Deebo Samuel and Raheem Mostert make a big difference. Nick Mullens played well last week and Buffalo's defense doesn't thrill me. Kyle Shanahan is doing a heckuva coaching job. Grab the points.

    Pick Made: Dec 02, 4:09 am UTC

    Team Injuries

    Buffalo Bills
    Tuesday, Mar 05, 2024
    Avatar
    OLB
    Matt Milano
    LegQuestionable
    Avatar
    OT
    Tommy Doyle
    KneeQuestionable
    Avatar
    SAF
    Taylor Rapp
    CalfQuestionable
    Avatar
    LB
    Baylon Spector
    BackQuestionable
    Avatar
    LB
    Terrel Bernard
    AnkleQuestionable
    Avatar
    WR
    Justin Shorter
    HamstringQuestionable
    Avatar
    CB
    Christian Benford
    KneeQuestionable
    Avatar
    TE
    Zach Davidson
    UndisclosedQuestionable
    San Francisco 49ers
    Tuesday, Mar 05, 2024
    Avatar
    SAF
    Tayler Hawkins
    WristQuestionable
    Avatar
    DT
    Kalia Davis
    AnkleQuestionable
    Avatar
    TE
    Cameron Latu
    Knee - MeniscusQuestionable
    Avatar
    DE
    Drake Jackson
    KneeQuestionable
    Avatar
    WR
    Danny Gray
    Shoulder - AC JointQuestionable
    Thursday, Feb 22, 2024
    Avatar
    CB
    Charvarius Ward
    UndisclosedQuestionable
    Tuesday, Feb 13, 2024
    Avatar
    NT
    Javon Hargrave
    ThumbQuestionable
    Avatar
    OT
    Nick Zakelj
    BicepsQuestionable
    Avatar
    SAF
    Talanoa Hufanga
    Knee - ACLQuestionable
    Monday, Feb 12, 2024
    Avatar
    LB
    Dre Greenlaw
    AchillesQuestionable