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Sun, Oct 128:25 pm UTCRaymond James Stadium
79 F
San Francisco
49ers
SF
Last 5 ATS
W/L8-4
ATS8-5
O/U7-6-0
FINAL SCORE
19
-
30
Tampa Bay
Buccaneers
TB
Last 5 ATS
W/L6-5
ATS5-7
O/U6-6-0
SPREAD
MONEYLINE
OVER/UNDER
Last 5 ATS
8-4
Win /Loss
6-5
8-5
Spread
5-7
7-6-0
Over / Under
6-6-0
SPREAD
MONEYLINE
OVER/UNDER

Simulation Picks

SPREAD
SF @ TB
Subscribers Only

Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks

MONEYLINE
SF @ TB
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OVER / UNDER
SF @ TB
Subscribers Only

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56%
PUBLIC
44%
MONEY
24%
PUBLIC
76%
MONEY
Over54%
PUBLIC
Under46%
Over
MONEY
Under

Understanding Public and Money

Think of 'Public' as the percentage of people betting on each side and 'Money' as how much money is being bet. When there's a big difference between the 'Public' and 'Money' data, it usually means that the more serious bettors (referred to as 'Sharp Money') are favoring a particular side.

Expert Picks

SpreadSan Francisco +3.5 -110
LOSS
Unit1.0
+248
16-12 in Last 28 NFL Picks
+233
27-22-1 in Last 50 NFL ATS Picks
Larry's Analysis:

Mac Jones continues to play efficiently and he’ll have Jauan Jennings in the lineup. The Bucs are terrific at late-game magic but it’s different when expecting them to cover a substantial number. They too are dealing with significant injuries. Look for a tight game and grab the points.

Pick Made: Oct 12, 7:14 pm UTC on BetMGM
SpreadSan Francisco +3.5 -110
LOSS
Unit1.0
+172
15-12-1 in Last 28 SF ATS Picks
Adam's Analysis:

The hook coming in makes the 49ers the play despite their continued personnel issues. Getting Jajuan Jennings back should mitigate the loss of Ricky Pearsall, and it seems like Kendrick Bourne figured something out with Mac Jones last week. The Buccaneers are perhaps not as good as their record suggests, and it took quite an implosion by the Seahawks for last week’s result. Kyle Shanahan should have the schematic advantage against Todd Bowles’ injured unit, and don’t forget, Tampa Bay is still down multiple key pieces in its own right. If San Francisco, which enters on extra rest and preparation time, can figure out a way to simply limit Emeka Egbuka, they may not only cover but win this outright.

Pick Made: Oct 12, 7:08 pm UTC on BetMGM
SpreadTampa Bay -3 -118
WIN
Unit1.0
+1226
37-22-2 in Last 61 NFL ATS Picks
+150
8-6 in Last 14 TB ATS Picks
Bruce's Analysis:

Some curiosities about these teams should be answered on Sunday. Regarding the 49ers, how long are they going to be able to hang in there with a patchwork lineup? Injuries have decimated the roster but here the Niners sit at 4-1 into this weekend, with Mac Jones (in again for ailing Brock Purdy at QB) now 3-0 as a starter, even minus the likes of Brandon Aiyuk and George Kittle. Meanwhile, the Bucs have mastered Perils of Pauline acts, with four last-minute wins in five games as orchestrated by QB Baker Mayfield, generating some deserving MLB buzz. Tampa Bay has injuries as well, but Mayfield also has an exciting new target, Ohio State rookie Emeka Egbuka, already on 5 TD catches. Play Bucs

Pick Made: Oct 12, 6:56 am UTC on BetRivers
SpreadSan Francisco +3.5 -111
LOSS
Unit1.0
+868.5
90-78-2 in Last 170 NFL Picks
Daniel's Analysis:

Now that the 49ers are catching 3 and the hook, I’ll take a chance on the road dogs to cover. The Bucs will be without RB Bucky Irving, WRs Mike Evans & Chris Godwin, and lose another starting DB in Zyon McCollum. This 4-1 Bucs team has relied on Baker Mayfield’s late game heroics, with all four of their wins coming by 3 or less. San Fran backup QB Mac Jones has been running Kyle Shanahan’s offense highly efficiently. Although the 49ers are also banged up on both sides of the ball, I trust their defensive unit much more than Tampa’s, who gave up 35 points to the Seahawks last week. The Bucs feel like a favorite whose luck may run out this week.

Pick Made: Oct 12, 3:20 am UTC on Caesars
Avatar
Receiving YardsSterling Shepard Over 30.5 Total Receiving Yards -114
WIN
Unit1.0
+1420.5
75-62 in Last 137 NFL Player Props Picks
Daniel's Analysis:

Shepard went over this receiving yards mark in each of his first 3 games this season. The Bucs are now extremely thin at wide receiver, and will be without Mike Evans & Chris Godwin for this game. While Jalen McMillan also remains sidelined, Baker Mayfield’s best downfield options are Shepard & Egbuka. Shepard has seen 4+ targets in each game thus far, and has been on the field for at least 60% of the offensive snaps in 4/5 weeks. If Shepard sees his typical 4-6 targets, he should go over this modest total.

Pick Made: Oct 12, 12:09 am UTC on DraftKings
Avatar
ReceptionsRachaad White Over 3.5 Total Receptions -132
LOSS
Unit1.0
+922
22-11 in Last 33 NFL Player Props Picks
Prop's Analysis:

FanDuel. With Bucky Irving slated to miss his second straight game, Rachaad White will once again assume the lead-back role. Last week, without Irving, White was on the field for 33 of Baker Mayfield’s 39 dropbacks, amassing four catches. In fact, between White and Bucky, the Bucs have had a running back clear this line in each of their five games this season. The 49ers have allowed 5.4 running back catches per game (5th most). With Chris Godwin and Mike Evans both out, Mayfield might have to rely even more on his running back in the passing game on Sunday.

Pick Made: Oct 10, 9:50 pm UTC on FanDuel

Team Injuries

San Francisco 49ers
Monday, Dec 01, 2025
Avatar
K
Eddy Pineiro
HamstringQuestionable
Avatar
LB
Tatum Bethune
AnkleQuestionable
Avatar
DT
Sam Okuayinonu
AnkleQuestionable
Avatar
OT
Ben Bartch
FootOut
Sunday, Nov 30, 2025
Avatar
FB
Kyle Juszczyk
RibsQuestionable
Avatar
LB
Nick Martin
ConcussionQuestionable
Tampa Bay Buccaneers
Friday, Dec 05, 2025
Avatar
CB
Benjamin Morrison
HamstringQuestionable
Wednesday, Dec 03, 2025
Avatar
OT
Tristan Wirfs
ObliqueQuestionable
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