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    Tue, Nov 221:15 am UTCEstadio Azteca
    Track OnCBS Sports
    San Francisco
    49ers
    SF
    Last 5 ATS
    W/L13-4
    ATS11-6
    O/U8-9-0
    FINAL SCORE
    --
    -
    --
    Arizona
    Cardinals
    ARI
    Last 5 ATS
    W/L4-13
    ATS8-9
    O/U7-9-1
    SPREAD
    MONEYLINE
    OVER/UNDER
    Last 5 ATS
    13-4
    Win /Loss
    4-13
    11-6
    Spread
    8-9
    8-9-0
    Over / Under
    7-9-1
    Key Injuries
    Key Injuries
    Avatar
    OG
    Key Injuries
    Avatar
    CB
    Avatar
    SAF
    Avatar
    CB
    SPREAD
    MONEYLINE
    OVER/UNDER

    Simulation Picks

    SPREAD
    SF @ ARI
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    MONEYLINE
    SF @ ARI
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    OVER / UNDER
    SF @ ARI
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    0%
    PUBLIC
    0%
    MONEY
    0%
    PUBLIC
    0%
    MONEY
    Over0%
    PUBLIC
    Under0%
    Over
    MONEY
    Under

    Expert Picks

    Point SpreadArizona +10 -110
    LOSS
    Unit1.0
    +1130
    59-43-5 in Last 107 NFL Picks
    +435
    40-32-3 in Last 75 NFL ATS Picks
    +325
    11-7 in Last 18 ARI Picks
    +85
    2-1 in Last 3 ARI ATS Picks
    Mike's Analysis:

    Arizona's scratch of QB Kyler Murray has sent the spread rocketing to +10, which offers value on the home side. Colt McCoy, a cut above most backups, was sharp last Sunday against the Rams as 'Zona deployed an effective short passing approach. The Cardinals tend to overachieve against their NFC West brethren, having covered in all but one of the last eight meetings as underdogs. Exuberance over the 49ers since they acquired RB Christian McCaffrey seems a bit extreme.

    Pick Made: Nov 21, 5:23 pm UTC
    Point SpreadArizona +10 -110
    LOSS
    Unit1.0
    +260
    6-3 in Last 9 NFL ATS Picks
    +204
    40-28 in Last 68 NFL Picks
    +143
    2-1 in Last 3 ARI Picks
    Matt's Analysis:

    Kyler Murray is not expected to play but I'm honestly not sure that matters at this spread -- Colt McCoy is generally decent. DeAndre Hopkins should go, so I think the Cards can hang within a TD in Mexico.

    Pick Made: Nov 21, 5:02 pm UTC
    Point SpreadArizona +10 -110
    LOSS
    Unit1.0
    +1320
    90-69-6 in Last 165 NFL ATS Picks
    +540
    11-5 in Last 16 ARI ATS Picks
    +240
    6-2 in Last 8 ARI Picks
    R.J.'s Analysis:

    Kyler Murray is not expect to play here, which caused this line to jump two points. But we said last week that Colt McCoy's success last year combined with his ability to operate within the offense might not make him a downgrade at QB despite the wide talent gap between the two players, then Arizona went out and took care of business in L.A. McCoy won in San Francisco last year 31-17 without DeAndre Hopkins, but the top receiver should be able to go in Mexico City. I had the 49ers at 6.5 points better in my power ratings heading into the week, and if there truly is no dropoff to McCoy playing in a better-run offense, then we're getting a lot of value here.

    Pick Made: Nov 21, 4:05 pm UTC
    Point SpreadArizona +8 -110
    LOSS
    Unit1.0
    +450
    10-5 in Last 15 NFL ATS Picks
    +430
    12-7 in Last 19 NFL Picks
    +170
    6-4-1 in Last 11 ARI ATS Picks
    +125
    13-10-1 in Last 24 ARI Picks
    Micah's Analysis:

    The Cardinals swept both games against the 49ers last season and are 7-1-1 ATS in their last nine vs. SF. I like the way Arizona matches up against the 49ers so the way I see it is I get a spread indicating Colt McCoy is most likely to start, and if he does, I’m fine with it. I saw him win two games last season in a similar fashion as last week. But then I’ll also be good if Kyler Murray is able to play and I’ll still have this large spread in my back pocket. Murray would be more focused after watching the Cardinals' best performance with someone else QB-ing his team. Might Murray try the quick releases, holding the ball for less than 2.3 seconds? Throw it quickly and then you don’t have to run around.

    Pick Made: Nov 17, 8:18 pm UTC
    Over / UnderUNDER 43.5 -110
    LOSS
    Unit1.0
    +230
    10-7-1 in Last 18 NFL O/U Picks
    +204
    40-28 in Last 68 NFL Picks
    +382.5
    7-2 in Last 9 SF Picks
    +242.5
    4-1 in Last 5 SF O/U Picks
    Matt's Analysis:

    The Niners have the No. 1 total defense in the NFL and likely will be facing a Cardinals team without starting QB Kyler Murray and for sure top tight end Zach Ertz, who is done for the season. We won't likely know on Murray for sure until later this week, but early reports are it probably will be Colt McCoy again. Offensively, San Francisco totaled just 17 points in both games last year vs. Arizona. Note this game is at altitude in Mexico City. Let's get this while it's still above 42.

    Pick Made: Nov 16, 5:34 pm UTC
    Point SpreadSan Francisco -8 -110
    WIN
    Unit1.0
    +468
    21-14 in Last 35 NFL Picks
    +100
    9-7 in Last 16 NFL ATS Picks
    Larry's Analysis:

    The 49ers didn't cover Sunday night versus the Chargers, but San Fran completely dominated the stat sheet in the 22-16 win. The Niners' red-zone inefficiency plus a penalty disparity contributed to the relatively small margin of victory. But now Kyle Shanahan's team returns to NFC West play, where it has covered five straight. I'm expecting Arizona to hold out Kyler Murray (hamstring) at least one more week, because Colt McCoy played so well in the 27-17 win over the Rams. But McCoy won't have any running game to lean on -- San Fran allows a league-low 3.4 yards per carry -- and this time he'll have to keep up with an elite offense that's poised to erupt. Lay the points.

    Pick Made: Nov 15, 4:24 pm UTC

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    Team Injuries

    San Francisco 49ers
    Monday, Nov 27, 2023
    Avatar
    OG
    Spencer Burford
    AnkleQuestionable
    Arizona Cardinals
    Monday, Nov 27, 2023
    Avatar
    CB
    Antonio Hamilton
    GroinQuestionable
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    SAF
    Joey Blount
    KneeQuestionable
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    WR
    Michael Wilson
    ShoulderQuestionable
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    DT
    Kevin Strong
    KneeQuestionable
    Sunday, Nov 26, 2023
    Avatar
    CB
    Starling Thomas V
    AnkleQuestionable