NFL | San Francisco 38 @ Arizona 10 | 11/22 | 1:15 AM UTC
San Francisco -8
ANALYSIS: The 49ers didn't cover Sunday night versus the Chargers, but San Fran completely dominated the stat sheet in the 22-16 win. The Niners' red-zone inefficiency plus a penalty disparity contributed to the relatively small margin of victory. But now Kyle Shanahan's team returns to NFC West play, where it has covered five straight. I'm expecting Arizona to hold out Kyler Murray (hamstring) at least one more week, because Colt McCoy played so well in the 27-17 win over the Rams. But McCoy won't have any running game to lean on -- San Fran allows a league-low 3.4 yards per carry -- and this time he'll have to keep up with an elite offense that's poised to erupt. Lay the points.