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Tue 11/22 | 1:15 AM UTC | Mexico City
SpreadMoney Lineo/u
San Francisco 49ers 15-5, 13-7 ATS
SF -9.5-110
SF -455
Over 43-110
Arizona Cardinals 4-12, 8-8 ATS
ARI +9.5-110
ARI +345
Under 43-110

Expert Picks

NFL | San Francisco 38 @ Arizona 10 | 11/22 | 1:15 AM UTC

San Francisco -8

WIN

ANALYSIS: The 49ers didn't cover Sunday night versus the Chargers, but San Fran completely dominated the stat sheet in the 22-16 win. The Niners' red-zone inefficiency plus a penalty disparity contributed to the relatively small margin of victory. But now Kyle Shanahan's team returns to NFC West play, where it has covered five straight. I'm expecting Arizona to hold out Kyler Murray (hamstring) at least one more week, because Colt McCoy played so well in the 27-17 win over the Rams. But McCoy won't have any running game to lean on -- San Fran allows a league-low 3.4 yards per carry -- and this time he'll have to keep up with an elite offense that's poised to erupt. Lay the points.

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Larry Hartstein

Senior Analyst
+440 43-34-3 IN LAST 80 NFL PICKS
+85 2-1 IN LAST 3 ARI ATS PICKS
+330 10-6 IN LAST 16 SF ATS PICKS
+328 9-5 on Props Picks

Season Splits

15-5, 13-7 ATS
4-12, 8-8 ATS
All Games
ALL
All Games
44%
4-5
5-5
50%
On Road or Neutral
LOCATION
On Road or Neutral
40%
2-3
3-2
60%
As Favorite
STATUS
As Underdog or PK
43%
3-4
4-3
57%
When Spread was -11.5 to -8.5
SPREAD
When Spread was +8.5 to +11.5
100%
1-0
0-0
0%
Favored on Road or Neutral
LOCATION & STATUS
As Road Underdog
25%
1-3
3-1
75%
vs Teams That Win 40-55% of Games
OPP WIN%
vs Teams That Win >55% of Games
33%
1-2
1-2
33%
vs Teams Allowing >25 PPG
OPP DEFENSE
vs Teams Allowing <21 PPG
0%
0-1
2-1
67%
After <=8 Days Off
REST
After <=8 Days Off
57%
4-3
5-3
62%
vs ARI
HEAD TO HEAD
vs SF
0%
0-0
0-0
0%