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No. 4 Ohio State travels to Bloomington for one of the most compelling Big Ten matchups of the 2026 season, visiting defending national champion Indiana in a Big Noon Kickoff showdown. The Buckeyes (5-1) arrive with quarterback Julian Sayin, who came within striking distance of the Heisman Trophy a season ago, looking to assert themselves against a program that claimed college football's ultimate prize just last winter. Indiana (6-0) turned to TCU transfer Josh Hoover, who has kept the Hoosiers undefeated and will look to make Memorial Stadium a hostile environment for the Buckeyes on Saturday. Claim the latest Polymarket promo code SPORTSLINE to get a $25 trading bonus after a $10 deposit:
Kickoff is set for noon ET at Memorial Stadium in Bloomington, Ind. Indiana are 3.5-point underdogs in the latest Ohio State vs. Indiana odds, with the over/under at 50.5 points.
Before making any Ohio State vs. Indiana picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It entered Week 7 on a 48-40 run on all top-rated college football picks, returning more than $400 for $100 players. Anybody following could have seen strong returns!
The model has simulated Ohio State vs. Indiana 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits 60% of simulations!
So who wins Ohio State vs. Indiana, and which side of the spread hits 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 48-40 run on top-rated CFB picks!
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