The Niners look like a potential juggernaut with all their offensive playmakers healthy, but Justin Herbert is no slouch. He's 3-0 ATS when getting 6-plus points, and here the Chargers are getting over a touchdown. They're 4-0 ATS on the road this season and have won four of their last five. While the Chargers sorely miss Mike Williams and Keenan Allen, Herbert should have time to find his other targets (Austin Ekeler, Josh Palmer, Gerald Everett, DeAndre Carter) with the Niners missing key defensive linemen. Take the points.

Prior to their bye week, the 49ers looked as dangerous as ever in a rout against the Rams. The addition of RB Christian McCaffrey is going to key plenty of drives for San Francisco. Yet, the 49ers have struggle outside of the NFC West, going 1-4. Look for their inability to execute outside the division to haunt them as the spread is far too big. Take the Chargers and the points.

There was already a fair amount of value on the Chargers, but the hook off a key number is a value-added bonus. This might be a poor stylistic matchup on paper, with the physical 49ers and recent addition Christian McCaffrey running into a finesse Chargers club. But short-handed Los Angeles played reasonably well last week despite looking determined at times to give the game away to Atlanta. Even so, the 49ers' style of play lends itself to a poor ATS record as a large favorite and Los Angeles is more than capable of keeping this a one-score game.

The 49ers have the No. 1 defense in the NFL, allowing only 285 yards per game. Chargers QB Justin Herbert has his two starting receivers out with injuries. But Los Angeles has managed well with the backup receivers, and Austin Ekeler has been the driving force. He has scored 10 touchdowns in the past five games, and the Chargers won four of them. They also have covered in their last four road games. I took the points with the Chargers.

The Chargers did what they were supposed to do last week in winning by three points. That makes four wins in their last five games since a major rash of injuries earlier in the season, and I think they've gotten to the point where they're underrated. That's reflected in the lookahead for this game being Chargers -4.5, them meeting expectations last week while the 49ers were off, and this line now sitting 2.5 points higher. I think that increase is due to a prediction of the 49ers seeing a big jump in value after getting to work Christian McCaffrey completely into the offense on the bye, but I had their rating very high already. I'd make this line 49ers -5, so nice value on L.A. here.