It's rare to get a value spot for one team against peak value for another, but that's the situation Thursday night. The Titans have struggled over their last four games after a hot start to the season, but return of A.J. Brown plus the clearance of Julio Jones should give the offense life as long as the left side of its line can hold up from some personnel losses. The 49ers, meanwhile, are surging but have shown vulnerability against passing attacks. Tennessee is strong as a home underdog under Mike Vrabel and benefits from the short week. The only reason it lost to Pittsburgh was turnovers. The hook makes this an even better call, and a moneyline sprinkle is worth considering.

I realize Tennessee has lost three of its last four and San Francisco has won five of six, but I like that the Titans are playing this game at home on a short week. Also, Tennessee's issue has been turnovers, but the 49ers are below average in takeaways. I'm on the Titans.

The 49ers are rolling in straight-up terms at 5-1. The Titans’ lone outright win in their last four contests came against league doormat Jacksonville. Tennessee QB Ryan Tannehill would be advised to wear body armor. The veteran, who has been sacked 41 times, will be missing the left side of his usual offensive line. With T Taylor Lewan (back) and G Rodger Saffold (COVID-19) sidelined, their backups must fend against Nick Bosa, who is tied for third in the NFL with 15 sacks. San Francisco sports a better SU record on the road (5-2) than at home (3-4).

The 49ers are on a roll, winning five of their last six games and easily taking care of the Falcons on Sunday. The Titans have lost three of four, including an ugly game against the Steelers. Last week's results were enough to swing this matchup 3.5 points off the lookahead, which I think gives zero credit to how well the Tennessee defense has played in those games. The Titans rush offense had another great day vs. Pittsburgh, and A.J. Brown is likely coming back this week. I love getting the hook with the Titans at home trying to fight to keep the AFC South lead in the final weeks, while fading a 49ers team at its peak market value.

This is just a perfect Mike Vrabel game, isn't it? The 49ers are playing their best football of the season and the Titans can't get out of their own way. When you dig deeper in the stats here this game is closer than most might think. Both teams are built to run the football and then exploit the passing game after...which falls right into Tennessee's defense. The Titans run defense allows around only 90 yards per game for 2nd best in the NFL. They also have 13 interceptions on the season. Tennessee's issues lately have been turnovers and OL pass-pro but San Francisco's defense doesn't really create that many turnovers. AJ Brown is eligible off IR and he's begging to play. The Titans' offense, through all of it's injuries (seriously look at what they've put on the field in recent weeks), is one playmaker from opening it back up. Give me Tennessee at home as a dog, on a short week vs. west coast travel, and coming off a dreadful performance I can assure you Mike Vrabel is still in their ears about.

The 49ers have won five of six, scoring at least 23 points in each game. In that span Jimmy Garoppolo has thrown 10 TDs against three INTs. On Sunday the 49ers fumbled the opening kickoff but shrugged it off en route to a 31-13 pasting of Atlanta. The Titans mustered 4.1 yards per play against the Steelers and have dropped three of four, beating only the lowly Jaguars. Wideout A.J. Brown (chest) might not return for this game, as Titans fans had hoped. Back San Francisco's balanced attack to get the job done.