If you can take 3.5 points or buy up, there is value. San Francisco lost too many big-time players last week to still be a favorite. QB Jimmy Garoppolo a 2.5-point drop to Nick Mullen and RB Raheem Mostert is a drop of 1.5 points. Last year, San Francisco averaged 1.5 less yards per play without Mostert. DE Nick Bosa is a 1.5-point player that dominates against the run and pressures the quarterback. Last season, the 49ers' defense allowed opponent passers to post a five-percent higher passing rating and running backs to gain almost a yard more per carry. It is time for Daniel "Dimes" Jones to pull out a win for the Giants.

The 49ers have four key players out, and while I think their offense will struggle without Jimmy Garoppolo the defense will still be stellar without Nick Bosa. The Giants offensive line has been horrendous and cannot open holes for anyone, which is why they have rushed for only 52.0 yards per game (worst in the NFL). Take the Under.

The Giants are putrid, yes, and will not have Saquon Barkley (done for year) or Sterling Shepard (IR). However, that Big Blue is getting 3.5 points at home against a Niners team missing Jimmy Garoppolo, Raheem Mostert, Tevin Coleman, George Kittle, Deebo Samuel, Nick Bosa, Dre Greenlaw, Dee Ford and Richard Sherman is a stunner. If New York can't at least cover against the Niners' JV team, then Joe Judge should be fired already. This line has plummeted since its opening of -6.5. Get it now before it drops to a field goal.

The 49ers just want to get home without losing any more players to injury. Their pass rush has been decimated, which should allow Daniel Jones to thrive. Look for Dion Lewis to be effective catching passes out of the backfield. For the Giants, this is a golden chance to get Joe Judge his first head-coaching win. Grab the points but don't be surprised by an outright win.

Both these teams are dealing with big losses on the offensive side of the ball, with the 49ers down a quarterback and two running backs to go with their issues at receiver. George Kittle might be able to return this week, but he can't carry the offense himself with Nick Mullens, who was not impressive in relief last week. The 49ers lost some key pass rushers but can still take advantage of the Giants' O-line, while the San Francisco back seven is talented enough to handle the weapons the Giants still have in place. This seems like a Kyle Shanahan run-fest that shortens the game and keeps it Under.

The injury gods punched enough holes in San Francisco's roster to make it look like a moth-eaten sweatshirt in Bill Belichick’s closet. The players who remain have voiced concerns over the turf at MetLife Stadium on which those injuries occurred last week against the Jets. They must negotiate the surface again this weekend, so they could play too cautiously. The Giants lost RB Saquon Barkley (ACL), but his output has been inconsistent. His absence will not be felt as much as some of the 49ers.