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Sun, Sep 165:00 pm UTCHighmark Stadium
Los Angeles
Chargers
LAC
Last 5 ATS
W/L0-0
ATS0-0
O/U0-0-0
FINAL SCORE
--
-
--
Buffalo
Bills
BUF
Last 5 ATS
W/L0-0
ATS0-0
O/U0-0-0
SPREAD
MONEYLINE
OVER/UNDER
Last 5 ATS
0-0
Win /Loss
0-0
0-0
Spread
0-0
0-0-0
Over / Under
0-0-0
SPREAD
MONEYLINE
OVER/UNDER

Simulation Picks

SPREAD
LAC @ BUF
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MONEYLINE
LAC @ BUF
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OVER / UNDER
LAC @ BUF
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0%
PUBLIC
0%
MONEY
0%
PUBLIC
0%
MONEY
Over0%
PUBLIC
Under0%
Over
MONEY
Under

Understanding Public and Money

Think of 'Public' as the percentage of people betting on each side and 'Money' as how much money is being bet. When there's a big difference between the 'Public' and 'Money' data, it usually means that the more serious bettors (referred to as 'Sharp Money') are favoring a particular side.

Expert Picks

Under 41.5 -105
LOSS
Unit1.0
+2450
202-148-2 in Last 352 NFL Picks
+91
2-1 in Last 3 NFL O/U Picks
Larry's Analysis:

Wish I'd jumped on this total earlier but I see the Bills focusing on their ground game and playing much better defense at home today. Look for something in the neighborhood of 24-13 Chargers.

Pick Made: Sep 16, 3:56 pm UTC on Consensus
Buffalo +7 -106
LOSS
Unit1.0
+853
53-40-2 in Last 95 NFL ATS Picks
+260
10-7 in Last 17 NFL ATS Picks
Micah's Analysis:

This is one of those games where perception is weighted so far from reality on one of the teams that I had to play the game. Buffalo got rocked 47-3 last week at Baltimore, but this is a new week, they're at home and they're not using QB Nathan Peterman. These are professionals and most of the Bills players were on the squad that made the playoffs last season. The Chargers are missing their best defensive player (Joey Bosa) and have to fly clear across the country and play a 10 a.m. PT game on Sunday. I'm taking the points.

Pick Made: Sep 15, 6:12 pm UTC on Consensus
Buffalo +7.5 -114
LOSS
Unit1.0
+459
10-5-2 in Last 17 NFL ATS Picks
+360
8-4 in Last 12 NFL ATS Picks
Mike's Analysis:

The Bills certainly didn't pass the eye test in week 1. However, my model says this number is inflated with the Chargers traveling across the country for an early start on the road in Buffalo. My numbers make the Bills +4.5 underdogs with Josh Allen take the reps at QB. The Chargers looked decent at times, but it's important to recognize that the Chiefs are a bottom five defense. Take the points and enjoy the significant +7.5 number.

Pick Made: Sep 14, 8:55 pm UTC on Consensus
Buffalo +7.5 -115
LOSS
Unit1.0
+2053
98-78-4 in Last 180 NFL Picks
+681
29-20-1 in Last 50 NFL ATS Picks
R.J.'s Analysis:

The Bills are awful. No question about it. Football Outsiders has them as more than twice as bad as any other team. And even using those numbers, this line is too high. The Chargers just aren't well-coached, and they're in a tough spot after losing to their biggest divisional rivals this season and playing a team they'll expect to blow out, despite being a West Coast team in a 1 p.m. game. I didn't see the Chargers do much to fix their run defense this offseason, so this could be a game where LeSean McCoy feasts.

Pick Made: Sep 14, 1:43 am UTC on Consensus
L.A. Chargers -7 -112
WIN
Unit1.0
+2425
44-18-4 in Last 66 NFL ATS Picks
+655
11-4 in Last 15 NFL ATS Picks
Mike's Analysis:

Never, ever give a touchdown to a home team -- except in rare situations like this one. Buffalo rookie QB Josh Allen could not even beat out Nathan Peterman for the gig last week. It turned disastrous for the Bills, and they have shoved in Allen as the starter behind a sieve-like offensive line. L.A. has elected to not rush ace sacksterJoey Bosa (foot) back this week, which is a favor to Buffalo, but the Chargers can afford to wait another week. The D has contributed to the team’s six straight Unders on the road. Four dropped passes, possibly two for TDs, doomed L.A. against Kansas City last Sunday. Won’t happen again.

Pick Made: Sep 13, 8:07 pm UTC on Consensus
Under 43 -110
LOSS
Unit1.0
+2053
98-78-4 in Last 180 NFL Picks
+281
5-2 in Last 7 NFL O/U Picks
R.J.'s Analysis:

The Bills are definitely going to be an Under team this year with their situation on offense, and they have a strong enough defense that I think will show up at home and keep this game under the total. The Chargers offense could need a half to wake up with this early start time, so the first-half Under in particular should be a wise investment.

Pick Made: Sep 12, 6:52 pm UTC on Consensus

Team Injuries

Los Angeles Chargers
Monday, Dec 15, 2025
Avatar
CB
Elijah Molden
HamstringQuestionable
Avatar
WR
Derius Davis
AnkleQuestionable
Avatar
OT
Trey Pipkins
AnkleQuestionable
Avatar
WR
Quentin Johnston
GroinQuestionable
Sunday, Dec 14, 2025
Avatar
SAF
R.J. Mickens
ShoulderQuestionable
Buffalo Bills
Monday, Dec 15, 2025
Avatar
LB
Terrel Bernard
ElbowQuestionable
Avatar
CB
Christian Benford
ToeQuestionable
Sunday, Dec 14, 2025
Avatar
DT
Jordan Phillips
AnkleQuestionable
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