RB Leipzig have struggled against elite opponents this season. They lost 4-1 to Real Madrid and 4-1 to Como in the Champions League, and they recently suffered a 6-1 defeat to Bayern Munich in the Bundesliga. That doesn’t bode well for their chances against Man City, who have fired in nine goals in three Champions League matches so far. Enzo Maresca’s men suffered a disappointing defeat to Brighton at the weekend, so they’ll be desperate to bounce back in Leipzig. They beat AEK Athens 5-1 in their last Champions League game, despite resting most of their key players, and they could rack up a similar scoreline against Leipzig.

Arsenal should have far too much quality for Slavia Prague to handle when the teams clash in the Czech capital this week. The Gunners are top of the Premier League table, with eight wins from nine games this season. They’ll be full of confidence after beating Liverpool 1-0 at Anfield on Sunday. Mikel Arteta’s men are unbeaten in their last 15 Champions League group stage matches, and they were runners-up in this competition last season. Slavia Prague have zero wins, one draw, and two defeats from three Champions League games so far, and they look out of their depth.

PSG should extend their winning streak to 10 games when they face Villarreal at Estadio de la Cerámica. The European champions have made a flying start to their group stage campaign, beating Slovan Bratislava 6-1, Man City 4-2, and Barcelona 4-2. They should have enough firepower to win this game comfortably. Villarreal are a decent team, but they've lost two out of three Champions League matches so far, and they could ultimately be outclassed.

Lazio are level with Inter Milan at the top of the Serie A table after picking up eight wins and a draw from nine games this season. They thumped Sassuolo 6-2 at the weekend, which should boost the players’ confidence. Cagliari have lost their last three games by a margin of at least two goals, so they could be outgunned in this game. They lost 2-0 when they last faced Lazio at the Stadio Olimpico, and they haven’t beaten Lazio since 2013, so this is a lopsided rivalry.

Aston Villa moved up to ninth in the Premier League table after beating Man City 2-1 last weekend. They’ve picked up three wins and a draw from their last four league games, so the players should be full of confidence right now. Unai Emery’s men are unbeaten at home since mid-September, and they should be too strong for Fulham when the teams meet at Villa Park on Saturday. Fulham moved out of the relegation zone after securing back-to-back wins against Hull and Coventry – two newly promoted teams – but facing Aston Villa on the road is a far tougher challenge. Villa have won their last five home games against Fulham, and they should extend that winning streak this weekend.

Bologna should pick up their first home win of the season when they host Monza at Renato Dall’Ara. The Rossoblù have won three of their last four Serie A games, but all of those victories came on the road. They produced a superb performance to beat AC Milan 4-2 at the San Siro on Sunday, which should give the players a lift. Their home form has been underwhelming, but they should still get the better of newly promoted Monza. The Biancorossi have lost three of their last four matches, and they’re coming off a heavy defeat to Napoli, so they could struggle to deal with Bologna's dangerous attackers.

This should be a complete mismatch. PSG are on an eight-game winning streak, which includes impressive victories over Man City, Barcelona, and Lyon. The Parisians are top of the Ligue 1 table, and they’re all but certain to win a sixth consecutive title this season. Le Havre are bottom of the table, with zero wins, two draws, and six defeats from eight games. They lost 3-0 on their last trip to the Parc des Princes, and they could suffer another heavy defeat this time around.

Inter Miami should extend their winning streak to four games when they take on New York Red Bulls this weekend. The Herons have moved up to second in the Eastern Conference table after beating DC United 4-0, New York City FC 2-0, and Atlanta United 3-1. Lionel Messi has scored four goals in his last three games, and he could tear RBNY’s defense apart. The Red Bulls are coming off back-to-back defeats against DC United and Toronto. They’ve lost seven out of 15 home games this season, conceding 29 goals in the process. Inter Miami have the best away record in Major League Soccer – nine wins, three draws, and only three defeats from 15 games on the road.

Over 3.5 goals has paid off in Real Betis' last three matches. They thrashed Osasuna 5-2 and battled to a 3-2 win against Porto, before losing 5-2 to Barcelona at the weekend. Los Verdiblancos are dangerous in attack, but their defense is weak. Over 3.5 goals has also landed in nine of Feyenoord's last 10 games. They beat Como 3-2 in their last Champions League match, before battling to a 4-3 victory over Telstar at the weekend.

It’s hard to see why the sportsbooks make PSG the slight underdogs for this game. They’re the reigning European champions, and their team is stacked with world-class players like Vitinha, Khvicha Kvaratskhelia, and Ousmane Dembélé. The Parisians have home advantage, and they’ll be much fresher than Barcelona for this game. Manager Luis Enrique benched nine of his 11 best players for their game against Strasbourg at the weekend, whereas Barça’s stars all played against Real Betis. Barça have made a superb start to the season in Spain, but they play a high defensive line, so PSG’s forwards could run riot.

Atlético Madrid have won their last six games, including away victories over Espanyol, Alavés, and Real Sociedad. They beat Man Utd 2-0 in their last Champions League match, so they should be full of confidence right now. Stuttgart are a decent team, but they could struggle to deal with Atlético's elite forwards in this game.

Bournemouth should have enough quality to pick up their first win of the Premier League season when they host Sunderland on Sunday. The Cherries picked up a morale-boosting 3-0 victory over Strum Graz in the Europa League on Thursday, but their domestic results have been poor. It has taken them a while to adjust to life under new manager Marco Rose, but they’ve also faced a difficult run of fixtures, including games against Man City, Liverpool, and Chelsea. They now have a golden opportunity to beat Sunderland, who are on a three-game losing streak in the Premier League. The Black Cats played away in Portugal on Thursday, so they could be tired, and they could be overrun in this game.

Venezia are bottom of the Serie A table after losing all six games so far this season. They've already conceded 16 goals, which doesn't bode well for their chances of stopping Kevin De Bruyne and Rasmus Højlund in this game. Napoli are coming off a disappointing midweek defeat to Villarreal in the Champions League, but their domestic form has been strong. They're on a three-game unbeaten streak in Serie A, including a 3-0 win against Frosinone last weekend, and they should outclass Venezia.

Over 2.5 goals has landed in seven of Atlético Madrid’s eight games this season. It has also paid off in all four of their away matches – a 3-1 win against Sevilla, a 3-0 defeat to Athletic Club, a 3-0 victory over Real Sociedad, and a 2-1 win against Alavés. Diego Simeone’s men aren’t particularly solid at the back these days, but they’re dangerous in attack, led by Julián Álvarez, Ademola Lookman, Jonathan David, and Alexander Sørloth. Over 2.5 goals has paid off in three of Espanyol’s home games. In total, their matches have averaged 2.75 goals this season, so this should be a high-scoring match.

Real Madrid have a superb record against Italian teams, with 20 wins from their last 22 games. Los Blancos picked up a morale-boosting victory over Villarreal at the weekend, so the players should be on a high right now. They've won seven out of nine games this season, including a 2-1 Champions League win against Inter Milan. Roma have made a strong start to the Serie A season, and they're currently third in the table, but they could be outclassed by the likes of Kylian Mbappé, Jude Bellingham, and Vinícius Júnior here.