Both of these teams have only lost one game to date in 2026. St. John's relies on a stout defense, holding five of its last seven opponents to 65 points or less. Duke has shown vulnerability in this tournament, with 16 seed Siena pushing them to the max in Round 1. The Red Storm have one of the greatest college basketball coaches of all-time in Rick Pitino and I suspect he will outsmart Jon Scheyer in this one. Not only do I think St. John's covers the 6.5 points, I think it wins outright. I also lean towards the Under. St. John's 68, Duke 65.