Tuipulotu logged six tackles (five solo), including 1.5 sacks, in the Chargers' 24-16 loss to the Bills on Sunday.
Smith accumulated five tackles (two solo) and two passes defensed for two interceptions in the Chargers' 24-16 loss to the Bills on Sunday.
Cashman (elbow) was a limited participant in Wednesday's practice.
James (hamstring) was a limited participant at practice Wednesday.
Mitchell (ankle) was a limited participant at the Chargers' practice Wednesday, Kris Rhim of ESPN.com reports.
McConkey was limited at Wednesday's practice due to a foot injury.
Thompson (quadriceps) did not practice Wednesday, Kris Rhim of ESPN.com reports.
Kolar (forearm) is not practicing Wednesday, Kris Rhim of ESPN.com reports.
Vikings head coach Kevin O'Connell said that Jefferson (ankle) won't practice Wednesday and is viewed as day-to-day.
Metellus recorded nine tackles (four solo), including 0.5 sacks, and a defensed pass Sunday against Tampa Bay in a 23-16 victory.
