Smith accumulated five tackles (two solo) and two passes defensed for two interceptions in the Chargers' 24-16 loss to the Bills on Sunday.
Simmons (back) did not participate in Wednesday's practice, Matt McMullen of the Chiefs' official site reports.
James (hamstring) was a limited participant at practice Wednesday.
Conner (knee) was a full participant at practice Wednesday.
Mitchell (ankle) was a limited participant at the Chargers' practice Wednesday, Kris Rhim of ESPN.com reports.
McConkey was limited at Wednesday's practice due to a foot injury.
Thompson (quadriceps) did not practice Wednesday, Kris Rhim of ESPN.com reports.
Kolar (forearm) is not practicing Wednesday, Kris Rhim of ESPN.com reports.
Bolton recorded 11 tackles (eight solo) and a pass breakup in Sunday's 24-10 win over the Dolphins.