Carson Wentz will go for the Colts, but with two sprained ankles, his mobility will obviously be limited. Some might say that also describes his ability. Head-to-head history seems to be playing into a lot of Indianapolis picks here, but that's ignoring the fact that the Colts have struggled stopping the run this year. With Derrick Henry coming in and Ryan Tannehill quite mobile himself, that is going to cause problems. After a Week 1 hiccup against the Cardinals, the Titans proved their might in a come-from-behind win on the road against the Seahawks last week. Back at home, give me Tennessee to continue winning … and Indianapolis to continue losing both on the field and against the spread (0-2).

Only one of six games between these teams in the last three years has come in Under 47 points. Going even further back, only three of the 12 meetings since 2015 have stayed below the number. The matchups between these division rivals has been historically high-scoring. My model has this one at 51.8, a meaningful edge, and I think we'll see a good number of scores as both offenses are going to have advantages against the defenses they are facing.

I have this one coming in at 2.9 in favor of the Titans, with minimal variance in my projections. This is a huge game for Indianapolis, which is looking to avoid an 0-3 start. I don't think Tennessee will lose, but it makes sense that this one comes in a bit closer to a field goal than a touchdown. Take the Colts and the points.

The Colts have absolutely owned the Titans in this matchup in previous years and although I don’t think the Colts are that great, I think this game should be close considering the teams know each other so well. Carson Wentz is playing but I think this game will be a grind it out, ground battle on both sides of the ball. Take the Colts to cover.

Indianapolis might have to play Jacob Eason and/or Brett Hundley if Carson Wentz (ankle) can't play. He didn't practice on Thursday, so he's not trending in the right direction. Also, in his last three games against the Colts, Titans running back Derrick Henry has rushed for more than 100 yards in each game for a total of 429 yards and four touchdowns. Tennessee is a well coached team that will be very good this year. I think the Titans cover this with no problem.

Carson Wentz seems doubtful to play in this game, and even if he can he should be hampered by injuries to both ankles. When he's ruled out, the line will move upward, so I'm going to jump on it now. While I typically think there's too much of an adjustment made to lines when backup QBs take the stage, the news that Brett Hundley took first-team reps on Wednesday and that he could feature in this game is a massive red flag for Jacob Eason's outlook. If that's not bad enough, the Colts defense ranks 32nd in adjusted line yards through two games, setting up a big day for Derrick Henry. With little confidence the Colts can storm through the back door, I'm going Titans.

It seems as if the Titans' offense and run game came alive against the Seattle Seahawks. They did an awesome job of getting off the mat and getting the victory. The Colts may or may not be with starting QB Carson Wentz after he sprained both ankles against the Rams. Even if he plays, he's been highly ineffective and now that he won't be able to move like he normally does, it would make him a sitting duck in the pocket.

Statistically these are two pretty even teams offensively. Rushing, passing, you name it the numbers are nearly identical. The difference is that Tennessee's offense hasn't even began to get started yet this year and the Colts have injury issues at both the QB and OL positions. The Titans offensive line isn't in much better shape, but that could actually play in its favor this week. Indy is giving up 145 yards per game on the ground and if Derrick Henry gets his, Tannehill will utilize the quick passing game to alleviate his banged up OL's burdens. Perfect "get right" game for Tennessee. At home. Against the one team they (and the crowd) would love to run up the score on.

A little risky making an NFL pick this early, but I say there's ZERO chance that Carson Wentz plays with both ankles sprained. That means Jacob Eason would start at quarterback, and he has not looked ready for the NFL yet either in the preseason or in relief of Wentz last week. That Titans defense isn't great but should overwhelm Eason and Tennessee will win by at least a TD. The favorite is 7-2 ATS in the past nine meetings.