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Sun, Sep 125:00 pm UTCFord Field
San Francisco
49ers
SF
Last 5 ATS
W/L10-7
ATS9-8
O/U8-8-1
FINAL SCORE
--
-
--
Detroit
Lions
DET
Last 5 ATS
W/L3-14
ATS11-6
O/U7-10-0
SPREAD
MONEYLINE
OVER/UNDER
Last 5 ATS
10-7
Win /Loss
3-14
9-8
Spread
11-6
8-8-1
Over / Under
7-10-0
SPREAD
MONEYLINE
OVER/UNDER

Simulation Picks

SPREAD
SF @ DET
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MONEYLINE
SF @ DET
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OVER / UNDER
SF @ DET
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0%
PUBLIC
0%
MONEY
0%
PUBLIC
0%
MONEY
Over0%
PUBLIC
Under0%
Over
MONEY
Under

Understanding Public and Money

Think of 'Public' as the percentage of people betting on each side and 'Money' as how much money is being bet. When there's a big difference between the 'Public' and 'Money' data, it usually means that the more serious bettors (referred to as 'Sharp Money') are favoring a particular side.

Expert Picks

Detroit +9 -110
WIN
Unit1.0
+1938
37-12 in Last 49 NFL ML Picks
+1076
22-10 in Last 32 NFL ATS Picks
Matt's Analysis:

I get why the Lions are such big underdogs, especially with their best offensive lineman out. However, I can't not take this many points at home in Week 1. Why? In the past five seasons, opening-week favorites of at least 8 are 1-8 ATS. Over the past 10: 5-14 ATS. Motor City Kitties with a backdoor cover. Note that a few sites have it at 9.5 and I'd like to potentially wait for that but we have a picks deadline.

Pick Made: Sep 12, 4:23 pm UTC on consensus
San Francisco -8 -110
PUSH
Unit1.0
+2450
202-148-2 in Last 352 NFL Picks
+300
3-0 in Last 3 NFL ATS Picks
Larry's Analysis:

This line probably hasn't hit its ceiling. Kyle Shanahan has had months to devise a gameplan against Dan Campbell's Lions. And now Detroit left tackle Taylor Decker is dealing with a finger injury that caused him to miss Thursday's practice. That spells trouble against Nick Bosa, Arik Armstead and Dee Ford. The Lions already are starting a rookie at right tackle. Detroit's defense, which gave up 32.4 points per game last season, should be a little better but is extremely young and will get burned by big plays. Lay the points.

Pick Made: Sep 10, 1:34 pm UTC on whnj
San Francisco -7.5 -110
WIN
Unit1.0
+1754
33-14-3 in Last 50 NFL ATS Picks
+411
22-16-2 in Last 40 NFL ATS Picks
Hammer's Analysis:

The 49ers made the Super Bowl two seasons ago but struggled last season with injuries and missed the playoffs. They're healthy again, and I think they will get back to their winning ways. I expect the San Francisco defense to give new Lions quarterback Jared Goff fits just like it did when he was with the Rams in the NFC West. 49ers big.

Pick Made: Sep 09, 3:02 pm UTC on whnj
Detroit +7.5 -115
LOSS
Unit1.0
+1895
12-1-1 in Last 14 NFL ATS Picks
+90
2-1 in Last 3 NFL ATS Picks
Jeff's Analysis:

The Lions have a very good offensive line and will be able to put some points on the board against a team that's learning a new defense. The 49ers also have a new offensive coordinator. I don't think having QBs Jimmy Garoppolo and Trey Lance splitting reps helps either. This line is super-inflated. Home teams getting at least seven points in Week 1 have been very profitable. Take the underdog Lions.

Pick Made: Sep 07, 11:12 pm UTC on whnj

Team Injuries

San Francisco 49ers
Wednesday, Apr 01, 2026
Avatar
QB
Kurtis Rourke
KneeQuestionable
Avatar
CB
Tre'Vius Hodges-Tomlinson
UndisclosedQuestionable
Avatar
WR
Jacob Cowing
HamstringQuestionable
Avatar
CB
Jakob Robinson
ForearmQuestionable
Avatar
SAF
Ji'Ayir Brown
HamstringQuestionable
Wednesday, Mar 11, 2026
Avatar
DT
Osa Odighizuwa
ElbowQuestionable
Thursday, Feb 12, 2026
Avatar
MLB
Fred Warner
AnkleQuestionable
Avatar
DE
Nick Bosa
Knee - ACLQuestionable
Avatar
TE
George Kittle
AchillesQuestionable
Avatar
TE
Jake Tonges
FootQuestionable
Avatar
LB
Tatum Bethune
GroinQuestionable
Avatar
DE
Mykel Williams
Knee - ACLQuestionable
Wednesday, Feb 11, 2026
Avatar
CB
Nate Hobbs
Knee - MCLQuestionable
Tuesday, Feb 10, 2026
Avatar
DE
Keion White
AnkleQuestionable
Detroit Lions
Wednesday, Apr 01, 2026
Avatar
DT
Alim McNeill
AbdomenQuestionable
Avatar
OT
Penei Sewell
AnkleQuestionable
Avatar
SAF
Thomas Harper
ConcussionQuestionable
Avatar
RB
Kye Robichaux
UndisclosedQuestionable
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