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    Sun, Sep 125:00 pm UTCFord Field
    Track OnCBS Sports
    San Francisco
    49ers
    SF
    Last 5 ATS
    W/L10-7
    ATS9-8
    O/U8-8-1
    FINAL SCORE
    --
    -
    --
    Detroit
    Lions
    DET
    Last 5 ATS
    W/L3-14
    ATS11-6
    O/U7-10-0
    SPREAD
    MONEYLINE
    OVER/UNDER
    Last 5 ATS
    10-7
    Win /Loss
    3-14
    9-8
    Spread
    11-6
    8-8-1
    Over / Under
    7-10-0
    Key Injuries
    Key Injuries
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    NT
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    LB
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    SAF
    Key Injuries
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    WR
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    LB
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    DB
    SPREAD
    MONEYLINE
    OVER/UNDER

    Simulation Picks

    SPREAD
    SF @ DET
    Subscribers Only

    Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks!

    MONEYLINE
    SF @ DET
    Subscribers Only

    Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks!

    OVER / UNDER
    SF @ DET
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    0%
    PUBLIC
    0%
    MONEY
    0%
    PUBLIC
    0%
    MONEY
    Over0%
    PUBLIC
    Under0%
    Over
    MONEY
    Under

    Understanding Public and Money

    Read More

    Think of 'Public' as the percentage of people betting on each side and 'Money' as how much money is being bet. When there's a big difference between the 'Public' and 'Money' data, it usually means that the more serious bettors (referred to as 'Sharp Money') are favoring a particular side.

    Expert Picks

    Point SpreadDetroit +9 -110
    WIN
    Unit1.0
    +1076
    22-10 in Last 32 NFL ATS Picks
    +912
    13-3-1 in Last 17 DET ATS Picks
    Matt's Analysis:

    I get why the Lions are such big underdogs, especially with their best offensive lineman out. However, I can't not take this many points at home in Week 1. Why? In the past five seasons, opening-week favorites of at least 8 are 1-8 ATS. Over the past 10: 5-14 ATS. Motor City Kitties with a backdoor cover. Note that a few sites have it at 9.5 and I'd like to potentially wait for that but we have a picks deadline.

    Pick Made: Sep 12, 4:23 pm UTC
    Point SpreadSan Francisco -8 -110
    PUSH
    Unit1.0
    +1787
    75-50 in Last 125 NFL Picks
    +1450
    67-47 in Last 114 NFL ATS Picks
    +740
    13-5 in Last 18 DET ATS Picks
    Larry's Analysis:

    This line probably hasn't hit its ceiling. Kyle Shanahan has had months to devise a gameplan against Dan Campbell's Lions. And now Detroit left tackle Taylor Decker is dealing with a finger injury that caused him to miss Thursday's practice. That spells trouble against Nick Bosa, Arik Armstead and Dee Ford. The Lions already are starting a rookie at right tackle. Detroit's defense, which gave up 32.4 points per game last season, should be a little better but is extremely young and will get burned by big plays. Lay the points.

    Pick Made: Sep 10, 1:34 pm UTC
    Point SpreadSan Francisco -7.5 -110
    WIN
    Unit1.0
    +705
    17-9 in Last 26 NFL Picks
    Hank's Analysis:

    The 49ers made the Super Bowl two seasons ago but struggled last season with injuries and missed the playoffs. They're healthy again, and I think they will get back to their winning ways. I expect the San Francisco defense to give new Lions quarterback Jared Goff fits just like it did when he was with the Rams in the NFC West. 49ers big.

    Pick Made: Sep 09, 3:02 pm UTC
    Point SpreadDetroit +7.5 -115
    LOSS
    Unit1.0
    +90
    2-1 in Last 3 NFL ATS Picks
    +700
    5-1 in Last 6 DET ATS Picks
    Jeff's Analysis:

    The Lions have a very good offensive line and will be able to put some points on the board against a team that's learning a new defense. The 49ers also have a new offensive coordinator. I don't think having QBs Jimmy Garoppolo and Trey Lance splitting reps helps either. This line is super-inflated. Home teams getting at least seven points in Week 1 have been very profitable. Take the underdog Lions.

    Pick Made: Sep 07, 11:12 pm UTC

    Team Injuries

    San Francisco 49ers
    Monday, Mar 25, 2024
    Avatar
    TE
    George Kittle
    GroinQuestionable
    Avatar
    CB
    Charvarius Ward
    GroinQuestionable
    Tuesday, Mar 05, 2024
    Avatar
    SAF
    Tayler Hawkins
    WristQuestionable
    Avatar
    DT
    Kalia Davis
    AnkleQuestionable
    Avatar
    TE
    Cameron Latu
    Knee - MeniscusQuestionable
    Avatar
    DE
    Drake Jackson
    KneeQuestionable
    Avatar
    WR
    Danny Gray
    Shoulder - AC JointQuestionable
    Tuesday, Feb 13, 2024
    Avatar
    NT
    Javon Hargrave
    ThumbQuestionable
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    OT
    Nick Zakelj
    BicepsQuestionable
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    SAF
    Talanoa Hufanga
    Knee - ACLQuestionable
    Monday, Feb 12, 2024
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    LB
    Dre Greenlaw
    AchillesQuestionable
    Detroit Lions
    Tuesday, Mar 05, 2024
    Avatar
    WR
    Kalif Raymond
    KneeQuestionable
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    DB
    Kerby Joseph
    ArmQuestionable
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    TE
    James Mitchell
    HandQuestionable
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    RB
    Jermar Jefferson
    UndisclosedQuestionable
    Tuesday, Feb 27, 2024
    Avatar
    LB
    Derrick Barnes
    KneeQuestionable
    Monday, Feb 12, 2024
    Avatar
    DB
    Emmanuel Moseley
    Knee - ACLQuestionable
    Monday, Jan 29, 2024
    Avatar
    LB
    Jalen Reeves-Maybin
    GroinQuestionable