San Francisco @ L.A. Rams

The bye week was a blessing -- not in disguise -- for the 49ers, with about 30 players landing on injured lists this season. This opponent is another blessing; though the Rams are in Super Bowl contention, they have dropped three straight to San Francisco. L.A. is far less rested, having returned home from their fifth East Coast commute this year after a Monday night win over Tampa Bay. The Niners have covered in seven of the last 10 as underdogs.

The 49ers are coming off of a bye and will look to cool off the red-hot Rams. In order for that to be the case, the Niners will once again rely on a quarterback not named Jimmy Garoppolo. With the way the Rams are playing defensively, it wouldn't even matter IF Garoppolo were to play in this game. The Rams are trying to create further distance between them and the rest of the NFC West.

Getting Deebo Samuel and Raheem Mostert back is a nice development for the 49ers that should help them going forward, but it should not make much difference on Sunday against a Rams squad that is clearly improving defensively. L.A. is 4-0 straight up and 3-1 ATS at home this season, and it has a full complement of players available in this game. The line is probably one point too high going in, but the Rams are likely to win this by double digits if everything shakes out according to projection.

The Rams are playing excellent football right now and are a perfect 4-0 at home this year. They will be trying to avenge a 24-16 loss to the 49ers and Jimmy Garoppolo in Week 6. But this is a very different matchup this time around. San Francisco, which comes into this game having lost three straight, has had trouble with injuries and COVID-19. The Rams are fresh and have won two straight over Seattle and Tampa Bay. Look for them to smash the 49ers here by double digits. San Francisco is just 1-6-1 ATS in its last eight November games. Los Angeles is 6-1-1 ATS in its last eight as a home favorite.