This one may get ugly for the Lions, which would probably keep this within the number if playing at 100% but are otherwise ravaged by injuries defensively. If you're getting obliterated by Mitch Trubisky at home, what's going to happen when Aaron Rodgers, Davante Adams, Aaron Jones and the Packers get a chance to feast in Lambeau Field? That's not even mentioning that Kenny Golladay is out, further crippling Matthew Stafford. I have the Packers as a nine-point favorite and think Green Bay takes this one easily. Though I missed the best line at -6 (and favor buying the half point if an inexpensive option), this is still below a full touchdown.

The Packers had an amazing Week 1, scoring 43 points against the Vikings, who I feel have a top-10 defense. This week, Aaron Rodgers takes on the bottom-five defense of the Lions. Detroit QB Matthew Stafford is one of the best in the NFL when his team is trailing by two or three touchdowns. This one should be back and forth because don't forget, the Packers gave up 34 points last week.

Detroit has been hit hard by injuries, particularly at the cornerback position, which is not what you want to see when you're about to face Aaron Rodgers in Lambeau Field. The Lions are also dealing with injury issues on the offensive side of the ball, where they could be without No. 1 receiver Kenny Golladay for another game as well as their starting right tackle. While I always worry Matthew Stafford will have it in him to cover through the back door as one of the better passers in this league, I think the odds favor Green Bay winning by at least a touchdown.

Green Bay's offensive line is dealing with key injuries, including losing starting guard Lane Taylor for the rest of the season, and the Packers shouldn't be laying so many points. The Packers allowed Minnesota to average a whopping 7.8 yards per play. Detroit has covered six straight meetings with Green Bay. Look for the Lions to bounce back strong from their heartbreaking loss to the Bears and at least keep this close.

My upset special. The Lions have covered the past six meetings, losing last year's matchups by 1 and 3 points. The Packers sustained a lot of injuries in their Week 1 win over Minnesota. They never play well against Detroit. Take the Lions.

Detroit is absolutely gutted due to injuries in the secondary and was torched in the fourth quarter of Week 1 by Mitchell Trubisky. What do you think Aaron Rodgers will do after demolishing a better Minnesota defense last Sunday? Detroit has lost 11 in a row as an underdog and is 2-10 ATS in its past 12 overall. Green Bay has won seven straight home openers (granted with fans) and is 5-1 ATS in its past six September games overall. This spread should be at -7, in my opinion, and the Pack should have little trouble winning by at least that much.