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nfl - Sun 09/13 | 8:25 PM UTC | Levi's Stadium |

Arizona @ San Francisco

Odds by William Hill Sportsbook
ATS
SF -6.5
-7.5
Over / Under
49
47
ML
SF -300
-330

Matchup breakdown

Arizona
SF
PROJ SCORE
8-7
W-L
6-9
7-8
ATS W-L
6-9
6-9
O/U
7-7
3.6
PT DIFF
-0.7
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Past Expert Picks

Larry Hartstein

Senior Analyst
Thu 9/10

Arizona @ San Francisco | 09/13 | 8:25 PM UTC

Arizona +7

WIN

The Cardinals are 4-0-1 ATS in the last five meetings, 5-0 ATS if you jumped on Arizona early enough leading up to the second meeting last season. San Francisco had a lot of trouble defending Kyler Murray last year, and now he has DeAndre Hopkins on his side. With the 49ers wideouts banged up, grab the points with another divisional underdog.

+1090 22-10-2 IN LAST 34 NFL ATS PICKS

Mike Tierney

Top Dog
Sat 9/12

Arizona @ San Francisco | 09/13 | 8:25 PM UTC

Arizona +7

WIN

Gifted quarterbacks tend to take the biggest leap forward in their second seasons, so expect fireworks from Kyler Murray, particularly with wide receiver DeAndre Hopkins coming aboard. The Cardinals’ receiving corps is ocean-deep, in contrast to the 49ers’ in this game. Top Target Deebo Samuel (foot) is a scratch. Brandon Aiyuk (hamstring) might be, too. While the hangover for Super Bowl runners-up might be mythical, this team is surely banged up for not having played yet. Heavy smoke from Northern California fires has disrupted practices leading up to the kickoff.

+325 23-18-3 IN LAST 44 NFL ATS PICKS

R.J. White

Super Stat Geek
Thu 9/10

Arizona @ San Francisco | 09/13 | 8:25 PM UTC

Arizona +7

WIN

I expect this line to come down, so if you like the Cardinals jump on them now. Arizona nearly beat San Francisco twice last season, and this version of the 49ers doesn't have nearly as much upside with its beat-up receiving corps. The Cardinals added a good amount of talent in the offseason, and they'll be hungry to prove they belong among the contenders in this division. The 49ers have also had to deal with the distraction of the wildfires in the area, which could even cause uncertainty on whether this game is played on time. There's too much to like with the Cards in this one.

+1750 80-56-5 IN LAST 141 NFL PICKS
+475 19-13 IN LAST 32 SF ATS PICKS

Tom Fornelli

#TrustTheProcess
Fri 9/11

Arizona @ San Francisco | 09/13 | 8:25 PM UTC

Arizona +7

WIN

Well this feels like a gift from the gods of odds. Did we not see how Arizona played against San Francisco last year? They lost one game by three, and another by 10, but Arizona led in the final minute of that 10-point loss. And then the Niners returned a fumble for a score on the final play of the game. Other than that, Arizona was a certified pain in the butt for the Niners, and now they've added De'Andre Hopkins. Sure, I'll take a touchdown. Thanks!

+85 3-2-2 IN LAST 7 NFL ATS PICKS
+551 12-6 IN LAST 18 SF ATS PICKS
+376 6-2 IN LAST 8 ARI ATS PICKS

Brett Anderson

The Dog Whisperer
Thu 9/10

Arizona @ San Francisco | 09/13 | 8:25 PM UTC

Arizona +7

WIN

The Cardinals played the 49ers close in both meetings last season, and Arizona has added DeAndre Hopkins along with several other new pieces. Kyler Murray should be even better in Year 2. Two Niners receivers, Deebo Samuel and rookie Brandon Aiyuk, are listed as questionable, while Emmanuel Sanders is now on the Saints. The Cardinals should at least be able to stay within a TD. Take the points.

Arizona

player
QBKylerMurray
16.84fan duel$7,700
17.59draft kings$6,400
18.57cbs sports
player
RBKenyanDrake
11.95fan duel$6,600
14.55draft kings$6,400
9.95cbs sports
player
RBChaseEdmonds
6.17fan duel$5,000
6.97draft kings$4,400
5.52cbs sports
PASSINGCP/ATTYDTDINTFUMLFP
K. MurrayKyler Murray22/351991.300.870.1318.6
RUSHINGRUSHYDTDYPCFUMLFP
K. DrakeKenyan Drake11.9480.404.00.1610.0
K. MurrayKyler Murray5.4350.166.50.1318.6
C. EdmondsChase Edmonds7.1280.253.90.095.5
RECEIVINGRECYDTDYPRFUMLFP
D. HopkinsDeAndre Hopkins6.7640.369.60.078.6
C. KirkChristian Kirk5.0480.269.50.066.8
L. FitzgeraldLarry Fitzgerald3.2290.209.00.034.1
K. DrakeKenyan Drake4.0250.096.20.1610.0
A. IsabellaAndy Isabella1.7230.1013.70.043.0
D. ArnoldDan Arnold1.5170.1611.60.022.7
DEF-STSACKINTFRECFGMFGAXP
A. DSTARI DST2.280.980.861.11.31.8

PLAYERS LISTED AS OUT OR DOUBTFUL:

KeeSean Johnson, Brett Hundley, Robert Alford, Deionte Thompson, Eno Benjamin
*Questionable players are included in the projection.

San Francisco

player
QBJimmyGaroppolo
16.47fan duel$7,400
17.31draft kings$5,800
19.09cbs sports
player
RBRaheemMostert
13.08fan duel$6,200
14.71draft kings$5,800
12.53cbs sports
player
RBTevinColeman
6.91fan duel$5,400
7.57draft kings$4,200
6.58cbs sports
PASSINGCP/ATTYDTDINTFUMLFP
J. GaroppoloJimmy Garoppolo21/292421.800.980.2919.1
RUSHINGRUSHYDTDYPCFUMLFP
R. MostertRaheem Mostert12.0700.655.80.1412.5
T. ColemanTevin Coleman9.0390.324.30.106.6
J. McKinnonJerick McKinnon7.0340.284.80.137.0
RECEIVINGRECYDTDYPRFUMLFP
G. KittleGeorge Kittle6.4820.3912.80.0710.6
J. ReedJordan Reed3.4390.2011.40.065.0
K. BourneKendrick Bourne2.8330.3911.90.035.7
K. JuszczykKyle Juszczyk2.3260.1511.10.053.6
T. TaylorTrent Taylor1.9180.129.20.032.4
J. McKinnonJerick McKinnon1.6160.0910.10.137.0
DEF-STSACKINTFRECFGMFGAXP
S. DSTSF DST4.030.871.071.92.22.8

PLAYERS LISTED AS OUT OR DOUBTFUL:

Deebo Samuel, Brandon Aiyuk, J.J. Nelson, Tavon Austin, Travis Benjamin, Ronald Blair, Kentavius Street, Jullian Taylor, Jason Verrett, Jalen Hurd
*Questionable players are included in the projection.

last updated: 09/13/2020 20:12 GMT