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    Sun, Sep 138:25 pm UTCLevi's Stadium
    Track OnCBS Sports
    Arizona
    Cardinals
    ARI
    Last 5 ATS
    W/L8-8
    ATS7-9
    O/U5-11-0
    FINAL SCORE
    --
    -
    --
    San Francisco
    49ers
    SF
    Last 5 ATS
    W/L6-10
    ATS7-9
    O/U8-8-0
    SPREAD
    MONEYLINE
    OVER/UNDER
    Last 5 ATS
    8-8
    Win /Loss
    6-10
    7-9
    Spread
    7-9
    5-11-0
    Over / Under
    8-8-0
    Key Injuries
    Key Injuries
    Avatar
    DE
    Avatar
    OG
    Key Injuries
    Avatar
    NT
    Avatar
    LB
    Avatar
    DT
    SPREAD
    MONEYLINE
    OVER/UNDER

    Simulation Picks

    SPREAD
    ARI @ SF
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    Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks!

    MONEYLINE
    ARI @ SF
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    Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks!

    OVER / UNDER
    ARI @ SF
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    0%
    PUBLIC
    0%
    MONEY
    0%
    PUBLIC
    0%
    MONEY
    Over0%
    PUBLIC
    Under0%
    Over
    MONEY
    Under

    Understanding Public and Money

    Read More

    Think of 'Public' as the percentage of people betting on each side and 'Money' as how much money is being bet. When there's a big difference between the 'Public' and 'Money' data, it usually means that the more serious bettors (referred to as 'Sharp Money') are favoring a particular side.

    Expert Picks

    Point SpreadArizona +7 -120
    WIN
    Unit1.0
    +280
    25-20-2 in Last 47 NFL Picks
    Mike's Analysis:

    Gifted quarterbacks tend to take the biggest leap forward in their second seasons, so expect fireworks from Kyler Murray, particularly with wide receiver DeAndre Hopkins coming aboard. The Cardinals’ receiving corps is ocean-deep, in contrast to the 49ers’ in this game. Top Target Deebo Samuel (foot) is a scratch. Brandon Aiyuk (hamstring) might be, too. While the hangover for Super Bowl runners-up might be mythical, this team is surely banged up for not having played yet. Heavy smoke from Northern California fires has disrupted practices leading up to the kickoff.

    Pick Made: Sep 12, 4:38 pm UTC
    Point SpreadArizona +7 -120
    WIN
    Unit1.0
    +175
    5-3-2 in Last 10 NFL Picks
    +85
    3-2-2 in Last 7 NFL ATS Picks
    +741
    15-7 in Last 22 SF ATS Picks
    Tom's Analysis:

    Well this feels like a gift from the gods of odds. Did we not see how Arizona played against San Francisco last year? They lost one game by three, and another by 10, but Arizona led in the final minute of that 10-point loss. And then the Niners returned a fumble for a score on the final play of the game. Other than that, Arizona was a certified pain in the butt for the Niners, and now they've added De'Andre Hopkins. Sure, I'll take a touchdown. Thanks!

    Pick Made: Sep 11, 6:37 pm UTC
    Point SpreadArizona +7 -115
    WIN
    Unit1.0
    +725
    22-13-2 in Last 37 NFL ATS Picks
    +270
    5-2-1 in Last 8 ARI ATS Picks
    Larry's Analysis:

    The Cardinals are 4-0-1 ATS in the last five meetings, 5-0 ATS if you jumped on Arizona early enough leading up to the second meeting last season. San Francisco had a lot of trouble defending Kyler Murray last year, and now he has DeAndre Hopkins on his side. With the 49ers wideouts banged up, grab the points with another divisional underdog.

    Pick Made: Sep 10, 7:07 pm UTC
    Point SpreadArizona +7 -115
    WIN
    Unit1.0
    +270
    7-4 in Last 11 SF ATS Picks
    Brett's Analysis:

    The Cardinals played the 49ers close in both meetings last season, and Arizona has added DeAndre Hopkins along with several other new pieces. Kyler Murray should be even better in Year 2. Two Niners receivers, Deebo Samuel and rookie Brandon Aiyuk, are listed as questionable, while Emmanuel Sanders is now on the Saints. The Cardinals should at least be able to stay within a TD. Take the points.

    Pick Made: Sep 10, 2:47 pm UTC
    Point SpreadArizona +7 -115
    WIN
    Unit1.0
    +1495
    82-60-5 in Last 147 NFL Picks
    +1160
    60-43-5 in Last 108 NFL ATS Picks
    +910
    38-28 in Last 66 SF ATS Picks
    R.J.'s Analysis:

    I expect this line to come down, so if you like the Cardinals jump on them now. Arizona nearly beat San Francisco twice last season, and this version of the 49ers doesn't have nearly as much upside with its beat-up receiving corps. The Cardinals added a good amount of talent in the offseason, and they'll be hungry to prove they belong among the contenders in this division. The 49ers have also had to deal with the distraction of the wildfires in the area, which could even cause uncertainty on whether this game is played on time. There's too much to like with the Cards in this one.

    Pick Made: Sep 10, 3:37 am UTC

    Team Injuries

    Arizona Cardinals
    Tuesday, Jun 18, 2024
    Avatar
    DE
    L.J. Collier
    BicepsQuestionable
    Tuesday, Jun 11, 2024
    Avatar
    OG
    Jon Gaines II
    Knee - ACLQuestionable
    San Francisco 49ers
    Tuesday, Jun 18, 2024
    Avatar
    NT
    Javon Hargrave
    ThumbQuestionable
    Avatar
    DT
    Kalia Davis
    AnkleQuestionable
    Avatar
    TE
    Cameron Latu
    Knee - MeniscusQuestionable
    Avatar
    DE
    Drake Jackson
    KneeQuestionable
    Wednesday, May 22, 2024
    Avatar
    TE
    George Kittle
    GroinQuestionable
    Monday, Mar 25, 2024
    Avatar
    CB
    Charvarius Ward
    GroinQuestionable
    Tuesday, Feb 13, 2024
    Avatar
    SAF
    Talanoa Hufanga
    Knee - ACLQuestionable
    Monday, Feb 12, 2024
    Avatar
    LB
    Dre Greenlaw
    AchillesQuestionable