Winn was scratched from the lineup for Wednesday's game in San Francisco due to left thumb soreness, Derrick Goold of the St. Louis Post-Dispatch reports.
Walker is absent from the lineup for Wednesday's contest in San Francisco.
Hjerpe will remain on a starter's schedule for the Cardinals down the stretch and is currently penciled in to serve in a piggyback role with Kyle Leahy, Derrick Goold of the St. Louis Post-Dispatch reports.
McLain went 1-for-3 with a stolen base in Tuesday's 3-2 loss to the Dodgers.
De La Cruz went 2-for-4 with a two-run home run and a double in Tuesday's 3-2 loss to the Dodgers.
Lodolo (3-4) allowed three runs on five hits, three walks and two hit batsmen while striking out six over 4.2 innings to take the loss Tuesday versus the Dodgers.
Mathews (1-3) allowed two runs on five hits and two walks while striking out four over six innings to take the loss versus the Giants on Tuesday.
The Cardinals activated Winn (thumb) from the 10-day injured list Tuesday.
Baez isn't in the lineup for Tuesday's game against the Giants.
The Cardinals optioned Prieto to Triple-A Memphis on Tuesday.
