Real Madrid are the most decorated club in Champions League history, but I expect Manchester City to secure the win at home. Man City battled Real Madrid to a 3-3 draw on the road in the first leg and they did so without superstar Kevin De Bruyne. Pep Guardiola’s side has scored 16 goals in their last four matches across all competitions and they’ve conceded just twice in their past four games at the Etihad. Man City recorded a 4-0 home win against Real Madrid in the UCL last season and I think they’ll do enough to claim victory again on Wednesday.

Atletico Madrid have been tough to beat on home soil this season and they’re coming off a thrilling 2-1 win at home over Inter Milan in the second leg of the Round of 16 tie. Borussia Dortmund have been inconsistent at best this season, which has BVB sitting in fifth place in the Bundesliga standings. With the second leg away at Dortmund’s hostile environment, I expect Antoine Griezmann and Memphis Depay to lead Atletico Madrid to victory in a tightly contested bout on home soil.

Arsenal have had trouble with Bayern Munich in the Champions League over the years, but the Gunners are playing well under Mikel Arteta ahead of Tuesday’s clash. Arsenal are unbeaten in their last seven matches across all competitions and they’ve kept a clean sheet in four straight games, which includes a 0-0 draw at Manchester City. Bayern are reeling after losing two straight in league play and Thomas Tuchel’s men suffered a 1-0 setback against Lazio in their last road match in this competition. I like the Gunners to win this one and take an advantage back to Munich for the second leg.

Signal Iduna Park will be rocking when Borussia Dortmund host PSV in the second leg of their Round of 16 tie on Wednesday. All is up for grabs after the two sides settled for a 1-1 draw in the first leg. PSV’s backline has been leaky away from home in this competition, conceding seven goals in three games. That bodes well for Dortmund, who’ve scored two or more goals in six of their last eight games across all competitions at home. I'm backing Borussia Dortmund to use the home crowd's energy to propel the German side to victory.

Arsenal enter Wednesday’s match flying high after securing five consecutive wins, which includes a 5-0 thrashing of Burnley on Saturday. The Gunners have scored three or more goals in four of their last five fixtures and now they’ll face a Porto side that is effective in the attacking third as well. Porto have scored two or more goals in six of their last seven matches and Over 2.5 goals were scored in four of Porto’s six group stage games in Champions League play. I expect Porto to come out with an aggressive game plan at home, leading to goals for both clubs.

Bayern Munich are coming off a 3-0 defeat against Bayer Leverkusen over the weekend, while Lazio snapped a three-game winless streak with a 3-1 victory over Cagliari. Bayern recorded a shoutout in their final two group stage fixtures and they’ll know a strong defensive outing on the road on Wednesday will give them the advantage in the second leg. Meanwhile, Lazio gave up just one goal in three group-stage matches on home soil, all of which finished Under 2.5 goals. That’s a trend I’m willing to back at +110 odds.

I think we’ll see a low-scoring affair when PSG host Real Sociedad in the Round of 16 on Wednesday. Real Sociedad have struggled mightily in the attacking third in recent weeks, failing to score in each of their last four games. La Real has also been extremely disciplined on defense, conceding just twice and recording four clean sheets in the UCL group stage. Plus, the Spanish side has recorded a shutout in nine of their last 11 away games. PSG is dangerous offensively with the likes of Kylian Mbappe, but Real Sociedad’s game plan will be to get to the second leg with a chance to spring an upset on home soil.

RB Leipzig know they’ll need a positive result at home against Real Madrid if they want to advance to the next round, which means they’ll be pressing for goals. RB Leipzig have scored two goals in each of their last four games, but they’ve conceded 10 times during that stretch. Real Madrid, meanwhile, have scored two or more in eight of their last nine matches in all competitions, a perfect recipe for Over 2.5 goals.

Atletico Madrid have scored eight goals in their two home fixtures in the Champions League, so I think they could potentially eclipse this total by themselves. Lazio, meanwhile, conceded three goals in their last match on the road in this competition, a 3-1 setback at Feyenoord. Nine of Atletico’s last 10 home games across all competitions this season have featured Over 2.5 goals, a trend I expect to continue on Wednesday.

Galatasaray and Copenhagen settled for a 2-2 draw in the reverse fixture and I expect we’ll see our fair share of goals on Tuesday. Galatasaray have scored three or more goals in three of their last four fixtures across all competitions and both teams are in the hunt for the knockout round. Copenhagen currently holds a one goal advantage over Galatasaray in goal differential, so I expect the Turkish side will be pressing forward looking to erase that deficit.

These two teams combined for five goals in the reverse fixture, a 3-2 victory for Galatasaray at Old Trafford. Man United know they need a victory on Wednesday if they want to keep their hopes of advancing to the knockout stages alive. The Red Devils gave up four goals to FC Copenhagen in their last away match in the Champions League and they’ve conceded three or more goals in three of their last six matches across all competitions. Galatasaray, meanwhile, are coming off a 4-0 victory over Alanyaspor over the weekend and Over 2.5 goals have been scored in six of their last seven matches in all competitions.

I’m not overthinking this one after watching these teams combine for five goals in the reverse fixture on Oct. 4. Feyenoord are averaging over 2.5 goals per game at home in all competitions this season and they’ve scored two or more in three of their four Champions League matches. Meanwhile, Atletico Madrid lead Group E with 12 goals and they’ve scored at least twice in 10 of their last 12 fixtures overall. I expect both teams to find the back of the net on Tuesday, so only one of these sides need to score twice.

Borussia Dortmund currently top the “Group of Depth” with seven points, while AC Milan ranks third with five. All four teams are within three points of each other, so this match will go a long way in determining which clubs advance to the knockout stage. Dortmund have been stellar defensively, conceding just twice in this competition. AC Milan, meanwhile, have scored only two goals in four UCL matches. Plus, Under 2.5 goals have been scored in five of AC Milan’s last six games on home soil.

Antwerp have yet to record a point in the group stage after conceding 14 goals in their first four matches. Antwerp suffered a 3-2 setback against Shakhtar Donetsk in the reverse fixture and I think the Ukrainian side could surpass this total by themselves on Tuesday. Shakhtar Donetsk can still qualify for the Round of 16 after pulling off a stunning 1-0 victory over Barcelona on Nov. 7, but they'll likely need a win here to advance, so I expect we’ll see Shakhtar deploy an attacking style of play. Plus, Over 2.5 goals have been scored in three of the four group stage games for both teams, a trend I see continuing on Tuesday.

Benfica have yet to score in the Champions League and they managed just three shots on target in the 1-0 loss at home against Real Sociedad on Oct. 24. In addition, Benfica controlled just 37% of possession in that match and I think they’ll find it tougher to create chances on the road. Real Sociedad have conceded just one goal in this competition and five of their last seven matches have featured Under 2.5 goals.