loading...
League Logo
NFL
League Logo
NFL
League Logo
CFB
League Logo
NBA
League Logo
CBB
League Logo
NHL
All
  • Loading...
loading...
Sun, Sep 278:25 pm UTCState Farm Stadium
100 F
Detroit
Lions
DET
Last 5 ATS
W/L5-11
ATS7-9
O/U10-6-0
FINAL SCORE
--
-
--
Arizona
Cardinals
ARI
Last 5 ATS
W/L8-8
ATS7-9
O/U5-11-0
SPREAD
MONEYLINE
OVER/UNDER
Last 5 ATS
5-11
Win /Loss
8-8
7-9
Spread
7-9
10-6-0
Over / Under
5-11-0
SPREAD
MONEYLINE
OVER/UNDER

Simulation Picks

SPREAD
DET @ ARI
Subscribers Only

Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks!

MONEYLINE
DET @ ARI
Subscribers Only

Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks!

OVER / UNDER
DET @ ARI
Subscribers Only

Maximize Your Odds of Winning with SportsLine Model and Our Top-Rated Picks!

0%
PUBLIC
0%
MONEY
0%
PUBLIC
0%
MONEY
Over0%
PUBLIC
Under0%
Over
MONEY
Under

Understanding Public and Money

Think of 'Public' as the percentage of people betting on each side and 'Money' as how much money is being bet. When there's a big difference between the 'Public' and 'Money' data, it usually means that the more serious bettors (referred to as 'Sharp Money') are favoring a particular side.

Expert Picks

Arizona -5.5 -110
LOSS
Unit1.0
+2577
84-53-4 in Last 141 NFL ATS Picks
+1696
48-28-2 in Last 78 NFL ATS Picks
Adam's Analysis:

Even with the return of Kenny Golladay, my concern is that the Lions will not have enough offense to keep up with the Cardinals over four quarters. Detroit's defense has struggled to this point, which makes me think Arizona will be able to attack it on the ground and through the air considering the bevy of weapons at Kyler Murray's disposal. The Packers proved last week that the Lions are no match for a multi-faceted offense. The Cardinals should be a touchdown favorite here, so I think there's a lot of value in rolling with Arizona at home.

Pick Made: Sep 27, 7:19 pm UTC on whnj
Under 55 -110
WIN
Unit1.0
+2053
98-78-4 in Last 180 NFL Picks
+281
5-2 in Last 7 NFL O/U Picks
R.J.'s Analysis:

This is a massive total for this matchup. The Lions have scored 44 points through two weeks, ranking 22nd in the league, while the Cardinals have given up just 35 points, the second-best mark in the NFL. Yes, Kenny Golladay appears on track to make his season debut, but I don't expect him near 100% as he's been limited in practice all week. Kyler Murray shouldn't have a ton of pushback against a Lions defense that's struggled, but this also seems like the type of game where Arizona takes the air out of the ball and churns up clock and yardage with Kenyan Drake, limiting the total amount of possessions in the game.

Pick Made: Sep 26, 1:21 am UTC on whnj
Detroit +5.5 -110
WIN
Unit1.0
+1158
29-16-1 in Last 46 NFL Picks
+208
13-10-2 in Last 25 NFL ATS Picks
Tom's Analysis:

The Lions are 0-2 after blowing leads in each of their first two games, and now they're hitting the road to take on a Cardinals team that's looked strong to start the season. The difference for Detroit this week will be the return of Kenny Golladay, as his absence has had a major impact on Matthew Stafford and an offense that loved to push the ball vertically last season. That element has been missing this year. It'll be back with Golladay, and while I don't know if the Lions get their first win, they'll get their first cover.

Pick Made: Sep 24, 2:15 pm UTC on whnj
Arizona -5.5 -110
LOSS
Unit1.0
+1754
33-14-3 in Last 50 NFL ATS Picks
+411
22-16-2 in Last 40 NFL ATS Picks
Hammer's Analysis:

The Lions have lost 11 straight games. They have no pass rush, their cornerbacks are hurt, and they're facing a Cardinals offense that's clicking with Kyler Murray, Kenyan Drake and DeAndre Hopkins. Arizona plays an up-tempo offense that Detroit can't possibly keep up with.

Pick Made: Sep 24, 2:27 am UTC on whnj

Team Injuries

Detroit Lions
Monday, Jan 05, 2026
Avatar
MLB
Alex Anzalone
ConcussionQuestionable
Avatar
OG
Kayode Awosika
IllnessQuestionable
Avatar
DT
Alim McNeill
AbdomenQuestionable
Avatar
OT
Penei Sewell
AnkleQuestionable
Avatar
SAF
Thomas Harper
ConcussionQuestionable
Sunday, Jan 04, 2026
Avatar
WR
Tom Kennedy
RibsQuestionable
Arizona Cardinals
Monday, Jan 05, 2026
Avatar
OG
Evan Brown
PersonalQuestionable
Sunday, Jan 04, 2026
Avatar
LB
Channing Tindall
KneeQuestionable
© 2026 CBS INTERACTIVE INC. ALL RIGHTS RESERVED. SportsLine and SportsLine PRO are registered trademarks of SportsLine.com, Inc.FANS ONLY
In partnership with...247 Sports

FOLLOW US:

The content on this site is for entertainment purposes only and SportsLine makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event. There is no gambling offered on this site. This site contains commercial content and SportsLine may be compensated for the links provided on this site.