For Chargers QB Philip Rivers, no Keenan Allen or Danny Woodhead to throw to. For Colts QB Andrew Luck, no Donte Moncrief. (And Luck has a bum shoulder.) Too many playmakers are missing or ailing for this game to carry a total of 51. The Chargers, in fact, have enough guys on injured reserve to conduct a 7-on-7 scrimmage -- flag football, of course. Rivers will hand off to RB Melvin Gordon, and the Colts will cut back on passing. That means Under.

The Chargers for a second year in a row are dealing to injuries to key offensive guys, but even so, the offense is in far better shape than the Colts defense. While they may get Vontae Davis back, they'll be without several key guys in the secondary. Andrew Luck won't have Donte Moncrief, and T.Y. Hilton's status is in jeopardy too. The Chargers secondary has been great in coverage this year and should continue against the Colts’ banged-up group. On the other side, Philip Rivers and Melvin Gordon should have no issue scoring on Indy’s injured, mediocre defense.