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Sat, Oct 127:30 pm UTCUnited Airlines Field at the LA Memorial Coliseum
Penn State
Nittany Lions
PSU
Last 5 ATS
W/L8-2
ATS6-7
O/U6-7-0
FINAL SCORE
33
-
30
USC
Trojans
USC
Last 5 ATS
W/L5-6
ATS7-5
O/U5-6-1
SPREAD
MONEYLINE
OVER/UNDER
Last 5 ATS
8-2
Win /Loss
5-6
6-7
Spread
7-5
6-7-0
Over / Under
5-6-1
SPREAD
MONEYLINE
OVER/UNDER

Simulation Picks

SPREAD
PSU @ USC
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MONEYLINE
PSU @ USC
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OVER / UNDER
PSU @ USC
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65%
PUBLIC
35%
MONEY
87%
PUBLIC
13%
MONEY
Over60%
PUBLIC
Under40%
Over
MONEY
Under

Understanding Public and Money

Think of 'Public' as the percentage of people betting on each side and 'Money' as how much money is being bet. When there's a big difference between the 'Public' and 'Money' data, it usually means that the more serious bettors (referred to as 'Sharp Money') are favoring a particular side.

Expert Picks

Point SpreadPenn State -3.5 -108
LOSS
Unit0.5
+344
8-5 in Last 13 NCAAF Picks
+183
4-2 in Last 6 NCAAF ATS Picks
+246
3-1 in Last 4 PSU ATS Picks
Mike's Analysis:

It's always tough to play a road game with significant travel, but ultimately, I don't think USC can keep up in the trenches. The USC offensive line ranks 128th out of 134 teams in terms of pass blocking, which is concerning against a Penn State defense that generates a lot of pressure. Penn State's running game will turn this into a matchup that will require an almost perfect performance from Miller Moss. I have Penn State favored by 6.7 points in this situation.

Pick Made: Oct 12, 3:46 pm UTC on DraftKings
Point SpreadPenn State -3.5 -110
LOSS
Unit1.0
+529
22-19 in Last 41 NCAAF Picks
+470
5-1 in Last 6 NCAAF ATS Picks
Gene's Analysis:

This is a bad matchup for USC. The Trojans already have lost to Big Ten teams with physical offensive lines and powerful rushing attacks in Michigan and Minnesota, and on Saturday they will get an even better version of that in Penn State. The Nittany Lions rank 18th in the country in rushing (217.8 yards per game). On the other side of the ball, Penn State has the ability to slow USC's passing game, allowing just 157.0 passing yards per game (11th best in the nation). I'll take the Nittany Lions.

Pick Made: Oct 12, 2:43 pm UTC on Caesars
Point SpreadPenn State -4.5 -115
LOSS
Unit1.0
+435
12-7 in Last 19 NCAAF Picks
+80
3-2 in Last 5 NCAAF ATS Picks
Chip's Analysis:

Penn State has a major advantage along the lines of scrimmage that will make it extremely difficult for USC to hang over the course of four quarters. Abdul Carter and the rest of this Nittany Lions front should be in Miller Moss' face all day and even if Penn State's offense is slow to get going on the West Coast road trip the ground game should be effective in the second half.

Pick Made: Oct 09, 7:14 pm UTC on FanDuel
Point SpreadUSC +5.5 -110
WIN
Unit1.0
+1441.5
78-58 in Last 136 NCAAF Picks
+814
34-24 in Last 58 NCAAF ATS Picks
Eric's Analysis:

This is a battle of what I consider two of the most overrated coaches in the sport: Lincoln Riley and Jame Franklin. I don't trust either very often but this matchup makes me take a stand. I like this spot coming off a loss for the Trojans in what I’ll consider a must win game to keep their (very) slim College Football Playoff hopes alive. Penn State usually dominates against every team not named Ohio State or Michigan, but traveling to the west coast against a CFB blue blood, let's extend that trend. I'll even call for the outright upset: USC 24, Penn State 23.

Pick Made: Oct 08, 11:49 pm UTC on BetMGM

Team Injuries

Penn State Nittany Lions
Saturday, Nov 29, 2025
Avatar
WR
Kaden Saunders
Undisclosed
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DT
Kaleb Artis
Undisclosed
Avatar
QB
Bekkem Kritza
Undisclosed
Avatar
DE
Jordan Mayer
Undisclosed
Avatar
QB
Jaxon Smolik
Wrist
Avatar
LB
Tony Rojas
Undisclosed
Avatar
S
Antoine Belgrave-Shorter
Undisclosed
Avatar
WR
Josiah Brown
Undisclosed
Avatar
WR
Peter Gonzalez
Undisclosed
Avatar
DE
Max Granville
Undisclosed
Avatar
OL
Liam Horan
Undisclosed
Avatar
RB
Jabree Coleman
Undisclosed
Thursday, Oct 16, 2025
Avatar
QB
Drew Allar
Ankle
USC Trojans
Sunday, Nov 30, 2025
Avatar
LB
Anthony Beavers Jr.
Undisclosed
Avatar
CB
Prophet Brown
Undisclosed
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OL
Kilian O'Connor
Undisclosed
Avatar
S
Bishop Fitzgerald
Undisclosed
Avatar
RB
Waymond Jordan
Ankle
Friday, Nov 28, 2025
Avatar
OL
Elijah Paige
Knee
Saturday, Nov 22, 2025
Avatar
S
Kamari Ramsey
Undisclosed
Avatar
K
Caden Chittenden
Hamstring
Thursday, Nov 06, 2025
Avatar
DT
Jamaal Jarrett
Undisclosed
Monday, Oct 13, 2025
Avatar
RB
Eli Sanders
Knee
Wednesday, Oct 01, 2025
Avatar
CB
Chasen Johnson
Knee
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