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Sun, Sep 0111:30 pm UTCAllegiant Stadium
USC
Trojans
USC
Last 5 ATS
W/L5-6
ATS7-5
O/U5-6-1
FINAL SCORE
27
-
20
LSU
Tigers
LSU
Last 5 ATS
W/L7-4
ATS4-8
O/U4-8-0
SPREAD
MONEYLINE
OVER/UNDER
Last 5 ATS
5-6
Win /Loss
7-4
7-5
Spread
4-8
5-6-1
Over / Under
4-8-0
SPREAD
MONEYLINE
OVER/UNDER

Simulation Picks

SPREAD
USC @ LSU
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MONEYLINE
USC @ LSU
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OVER / UNDER
USC @ LSU
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61%
PUBLIC
39%
MONEY
84%
PUBLIC
16%
MONEY
Over61%
PUBLIC
Under39%
Over
MONEY
Under

Understanding Public and Money

Think of 'Public' as the percentage of people betting on each side and 'Money' as how much money is being bet. When there's a big difference between the 'Public' and 'Money' data, it usually means that the more serious bettors (referred to as 'Sharp Money') are favoring a particular side.

Expert Picks

Point SpreadLSU -3.5 -118
LOSS
Unit1.0
+529
22-19 in Last 41 NCAAF Picks
+470
5-1 in Last 6 NCAAF ATS Picks
Gene's Analysis:

Both teams are replacing Heisman Trophy-winning quarterbacks, and both are coming off poor seasons defensively. But the difference in this game, I believe, will be the Tigers' offensive line. LSU returns four of five starters on the front, which should be one of the best in the country. Quarterback Garrett Nussmeier should benefit from that continuity. Give me the Tigers.

Pick Made: Sep 01, 10:50 pm UTC on FanDuel
Over / UnderUnder 67 -105
WIN
Unit1.0
+292
5-2 in Last 7 NCAAF Picks
Bob's Analysis:

This won’t be the most popular pick. However, these two teams begin this season with new quarterbacks. LSU was the best offense in the country last season, averaging 45.5 points a game and the Trojans defense allowed 34.38 points per game. The public seems to be putting a lot of weight into what these teams looked like last season while each team lost some explosive offensive player makers. LSU’s defense should be even better than last year as Miller Moss has a difficult test to start the season.

Pick Made: Sep 01, 8:40 pm UTC on Caesars
Over / UnderOver 64 -112
LOSS
Unit1.0
+1624
64-43-3 in Last 110 NCAAF Picks
Bruce's Analysis:

There has been some upward movement in the "total" for this opener in Vegas, and for good reasons. Even with new QBs both ways, it's hard to overlook recent "over" trends for each. For USC, it's 21-6 across its last 27 games; for LSU, it's 19-2 across its last 21 games (what must Les Miles be thinking?). The respective new QBs, Miller Moss (Trojans) and Garrett Nussmeier (Tigers), both had test runs last bowl season and passed with flying colors as they go about replacing the last two Heisman winners (Caleb Williams and Jayden Daniels, respectively). With defensive issues yet to be answered by bath Lincoln Riley and Brian Kelly, the stage is set for a deluge of points, Play USC-LSU "Over" (at Las Vegas)

Pick Made: Sep 01, 3:06 pm UTC on DraftKings
Over / UnderOver 63.5 -112
LOSS
Unit1.0
+759
40-38 in Last 78 NCAAF Picks
+60
5-4 in Last 9 NCAAF O/U Picks
Tom's Analysis:

This game is the Spiderman meme. Two identical teams pointing at each other. Both can score points, and both love to give them right back to the opponent. Maybe they both improve defensively this season, but they won't look a lot better this week.

Pick Made: Aug 29, 5:27 pm UTC on BetRivers
Point SpreadLSU -6 -105
LOSS
Unit1.0
+649
14-7 in Last 21 NCAAF ATS Picks
+75
4-3 in Last 7 USC ATS Picks
Micah's Analysis:

This bet on LSU is all about the offensive line which returns four starters from last year and a starting tight end from the last 3 years. Garrett Nussmeier showed in the bowl game last year that he is ready to take over throwing for 395 yards and he's going to have a new hookup link in LSU tradition with CJ Daniels, a transfer from Liberty who had over a thousand yards receiving. Thirteen starters return overall. I think what I like most about the new defensive frontline is that they're all seniors and then the secondary has three of four starters returning. The defense will be better than last year. LSU covers.

Pick Made: Aug 18, 9:23 pm UTC on WilliamHillNewJersey
Over / UnderOver 62.5 -110
LOSS
Unit2.0
Jimmie's Analysis:

Caleb Williams and Jayden Daniels are gone, but with Lincoln Riley and Brian Kelly coaching, I still expect plenty of offensive fireworks in this season opener for both teams at Allegiant Stadium in Las Vegas. Miller Moss is likely stepping in at QB for USC and Garrett Nussmeier for LSU -- both have looked good when called upon as backups. Both teams here enter the season with massive question marks on the defensive side of the ball, which is why I believe this number should be closer to 70. This is a game I see ending with a final score in the 40-35 range.

Pick Made: Aug 05, 4:44 pm UTC on FanDuel

Team Injuries

USC Trojans
Tuesday, Dec 02, 2025
Avatar
RB
Bryan Jackson
Transfer Portal
Sunday, Nov 30, 2025
Avatar
LB
Anthony Beavers Jr.
Undisclosed
Avatar
CB
Prophet Brown
Undisclosed
Avatar
OL
Kilian O'Connor
Undisclosed
Avatar
S
Bishop Fitzgerald
Undisclosed
Avatar
RB
Waymond Jordan
Ankle
Friday, Nov 28, 2025
Avatar
OL
Elijah Paige
Knee
Saturday, Nov 22, 2025
Avatar
S
Kamari Ramsey
Undisclosed
Avatar
K
Caden Chittenden
Hamstring
Thursday, Nov 06, 2025
Avatar
DT
Jamaal Jarrett
Undisclosed
Monday, Oct 13, 2025
Avatar
RB
Eli Sanders
Knee
Wednesday, Oct 01, 2025
Avatar
CB
Chasen Johnson
Knee
LSU Tigers
Tuesday, Dec 02, 2025
Avatar
WR
Kylan Billiot
Transfer Portal
Avatar
WR
Jelani Watkins
Transfer Portal
Saturday, Nov 29, 2025
Avatar
QB
Garrett Nussmeier
Abdomen
Avatar
WR
Nic Anderson
Undisclosed
Avatar
WR
Aaron Anderson
Undisclosed
Avatar
OL
Braelin Moore
Undisclosed
Thursday, Nov 27, 2025
Avatar
RB
JT Lindsey
Suspension
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