The 49ers should take care of their end. WR Deebo Samuels and RB Elijah Mitchell return from injury-caused layoffs. RB Christian McCaffrey, absent from two practices this week, did not show up on the latest injury report and is good to go. The Cardinals allow 25.7 points per game, fourth most in the league. Their QB, David Blough, got the rust off in his first start in nearly two seasons last Sunday and should be more at ease. A total under 40 usually means two shaky offenses or two stout defenses. Neither applies here.