ANALYSIS: The Cardinals enter this game with one of the most potent offenses in the NFL, a clean sheet straight up and a 3-1 mark ATS. The 49ers are nearly the opposite at 2-2 on the season with victories over the winless Lions and Eagles, along with a 1-3 ATS streak. Oh, let's add a rookie QB in Trey Lance making his first start and San Francisco's most potent offensive weapon, TE George Kittle, on the IR. Is this line a bit inflated? Sure, by about one point. It's always scary to trust a coach like Kliff Kingsbury with a spread over a field goal, but Arizona's defense is solid enough to contain Lance and give its potent offense enough chances to cover these points.