These teams are clearly going in different directions. The Titans haven't looked great offensively in weeks, and Marcus Mariota is dealing with a knee injury, which could explain his poor play. San Francisco just won two straight road games and seem to have taken a huge step forward with Jimmy Garoppolo at quarterback. The Titans have scored more than 24 just once since Week 3 (that Monday nighter against the Colts in October), and the 49ers' defense hasn't allowed more than 24 points in five straight games. If the 49ers score 24 here, it feels like they'll get the cover, and I'll bank on that happening.

Although the 49ers are dressing up in the unfamiliar role of favorites, I'm going to continue backing Jimmy Garoppolo and fading the overrated Titans. Especially with this line below the key number. Tennessee has covered three of its past 10 games, and two of those were fluky last-minute covers.

This game features two teams going in opposite directions, as the 49ers and Titans collide Sunday. Newfound Confidence has come for San Francisco in the form of QB Jimmy Garoppolo. While he hasn’t lit the world on fire, he’s bought some stability to the offense and it has helped the defense as a result. The Titans are fighting their own battles of inconsistency, which will not help them in this game.