I'm bullish on both of these pitchers long term, but I have some concerns with Jesus Luzardo in this particular matchup and his strikeout rate and 1.58 HR/9 against right-handed hitting. Javier will benefit from the strong pitching environment in Oakland. I make the Astros +112 as I have them winning 47 percent of simulations in this matchup.

Tension between AL West rivals in the Astros and A’s made for compelling regular and postseason baseball last season. They’ll start off the 2021 season as the A’s look to avenge a playoff series loss against the Astros. While Zack Greinke’s form is not of elite caliber anymore, he’ll get the run support necessary to put the Astros in the win column.