Francis Ngannou will try to knock off all-time great Stipe Miocic in the featured heavyweight bout on Saturday night at UFC 260. Miocic won by decision in their first matchup three years ago, and the main card is scheduled to begin at 10 p.m. ET. Ngannou is a -125 favorite (risk $125 to win $100), while Miocic is a +105 underdog (risk $100 to win $105) in the latest UFC 260 odds from William Hill Sportsbook.

Before making any picks for UFC 260, you NEED to see the UFC predictions from SportsLine MMA expert Brandon Wise. He specializes in picking main-card fights for UFC, which has enabled him to be profitable every year! In fact, Wise went a perfect 5-0 at UFC 239 and was 4-1 at both UFC 245 and UFC 249. He also nailed Khabib Nurmagomedov's destruction of Conor McGregor in 2018, Stipe Miocic's defeat of Daniel Cormier, Max Holloway's downfall in 2019 and Justin Gaethje's TKO victory over Tony Ferguson in May of last year.

Since the UFC returned in May 2020 following a six-week period of inactivity due to the coronavirus pandemic, Wise has gone 66-42-2 while nailing the method of victory 48 times! At UFC 256, Wise went 4-0-1 (the main event was a draw) and correctly nailed the method of victory in three of those winners! Those selections included calling a decision victory for Charles Oliveira (+145) against Tony Ferguson (-165) in the lightweight co-main event. At UFC 257, he correctly called a stoppage victory for Makhmud Muradov (-145) against Andrew Sanchez (+125) in a matchup of middleweight prospects on the main card.

For UFC 260, we can tell you Wise is backing Sean O'Malley (-330) to have little trouble with Thomas Almeida (+250). Parlay his top picks together and you're looking at a strong payout of almost 15-1! You ABSOLUTELY need to see Wise's picks before making any of your own!

Who wins Ngannou vs. Miocic and every bout on Saturday's main UFC 260 card? And which parlay picks would return 15-1? ... Join SportsLine now to see which fighters you need to be all over at UFC 260, all from the accomplished MMA analyst who has been profitable for six straight years!