The Detroit Tigers will look to turn their road fortunes around when they battle the Houston Astros in the third and final game of their series Wednesday. The Tigers (18-12), who lead the American League Central, are just 5-9 on the road in 2025. The Astros (16-13), who have a plus-16 run differential, are 11-6 on their home field this season.

First pitch from Daikin Park in Houston is set for 2:10 p.m. ET. Houston is a -125 favorite on the money line (risk $125 to win $100) in the latest Tigers vs. Astros odds from Fanduel Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 8.5. Before making any Tigers vs. Astros picks, or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 6 of the 2025 MLB season on a 17-11 run on top-rated MLB picks (+276). Anybody following could have seen strong returns!

The model knows Houston is expected to either call up A.J. Blubaugh for a spot start or have a bullpen game, since the Astros have Thursday off. In four starts at AAA Sugar Land of the Pacific Coast League, he is 2-2 with a 3.86 ERA. In 12 starts at Sugar Land in 2024, he was 12-4 with a 3.83 ERA. In four minor league seasons, he has gone 22-10 with a 4.02 ERA in 65 games, including 44 starts.

The model also knows Detroit is expected to counter with right-hander Jackson Jobe (2-0, 2.70 ERA). In his last outing, a 7-3 win over the Kansas City Royals, he picked up the victory, pitching five innings and allowing five hits, one earned run and two walks, while striking out five. He also earned a win in a 4-0 triumph at Minnesota on April 12. In that game, he went six innings, allowing just two hits and one walk, while striking out two.

The model has simulated Tigers vs. Astros 10,000 times and the results are in. We can tell you the model is leaning Over on the run total, and it also says one side of the money line has ALL the value!

Who wins Tigers vs. Astros, and which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on an 17-11 run on top-rated MLB picks!