NFL picks: The 49ers are among expert's best spread bets for Wild Card Weekend

The road to Super Bowl 60 starts now, with NFL Super Wild Card Weekend kicking off Saturday. The action starts at 4:30 p.m. ET with Rams vs. Panthers, and Packers vs. Bears is also set for Saturday, kicking off at 8 p.m. ET. Sunday features three games -- Bills vs. Jaguars (1 p.m. ET), 49ers vs. Eagles (4:30 p.m. ET) and Chargers vs. Patriots (8 p.m. ET). Texans vs. Steelers wraps up the action on Monday night at 8:15 p.m. ET.   

The Philadelphia Eagles are the NFC East champions, while the San Francisco 49ers missed a chance to win the NFC's top seed when they lost to the Seattle Seahawks in Week 18. The Packers vs. Bears matchup at Soldier Field in Chicago is one of three games NFL betting expert Mike Tierney, who is 12-6 over his last 18 NFL spread picks (+526), is targeting for his NFL Wild Card Weekend best bets. Tierney has issued three against-the-spread best bets, also including Bills vs. Jaguars and Texans vs. Steelers. Here's what Tierney has to say about the NFL Wild Card Round and his expert best bets. 

So what are Mike Tierney's best bets for the 2025 NFL season's NFL Wild Card Weekend? Join SportsLine right now to see picks from an expert who is 12-6 in his past 18 NFL picks!