NFL picks: Bears vs. 49ers is among expert's best spread bets for Week 17

In NFL Week 17, most teams are either looking toward the NFL Draft or fighting for playoff seeding. Among the teams clawing to get to the top in the NFC are the Chicago Bears and San Francisco 49ers, who face off on Sunday Night Football. Both teams are 10-4 and one game behind the 11-3 Seattle Seahawks, who face what could be a test against the Carolina Panthers (8-7). The Panthers need to win to set up a showdown for the NFC South title next week at Tampa Bay, with the loser missing the postseason. The Bills (11-4) and Philadelphia Eagles (10-5) also meet Sunday in a cross-conference battle that could be a statement game for the victor.

Bears vs. 49ers is set for 8:20 p.m. ET on Sunday at Levi's Stadium in Santa Clara, Calif.  The NFC showdown is one of three games that NFL betting expert Mike Tierney, who is 7-1 over his last five NFL spread picks (+584), is targeting for his Week 17 best bets. Tierney has issued three against-the-spread best bets for Week 17, also including Jaguars vs. Colts and Patriot vs. Jets. Here's what Tierney has to say about Week 17 and his expert best bets. 

So what are Mike Tierney's best bets for Week 17 of the 2025 NFL season? Join SportsLine right now to see picks from an expert who is 7-1 in his past eight NFL picks!