NFL picks: Bills vs. Broncos among expert's best spread bets for Divisional Round of NFL Playoffs

The road to the Super Bowl in 60 at Levi's Stadium in Santa Clara, Calif., continues this weekend with the NFL Divisional Round. There are two games on both Saturday and Sunday, with the top-seeded Denver Broncos and Seattle Seahawks returning to action after first-round byes. Bills vs. Broncos kicks off the NFL Playoffs action at 4:30 p.m. on Saturday, followed by 49ers vs. Seahawks at 8 p.m. ET. Buffalo surged past the Jacksonville Jaguars 34-31 last weekend, while San Francisco knocked off Philadelphia 23-19 to set up a third meeting this season with NFC West rival Seattle.      

Fellow NFC West denizens the Los Angeles Rams head to Soldier Field on Sunday night to face the Chicago Bears at 8 p.m. ET. That comes after the New England Patriots host the Houston Texans at 4:30 p.m. ET. Bills vs. Broncos is one of the three games NFL betting expert Mike Tierney, who is 14-7 over his last 21 NFL spread picks (+606), is targeting for his NFL Divisional Round best bets. Tierney has issued three against-the-spread best bets, also including 49ers vs. Seahawks and Texans vs. Patriots. Here's what Tierney has to say about the NFL Divisional Round and why he left Rams vs. Bears out of his expert best bets. 

So what are Mike Tierney's best spread bets for the 2025 NFL season's NFL Divisional Round? Join SportsLine right now to see picks from an expert who is 14-7 in his past 21 NFL picks!