The top two leading contenders for the American League Cy Young award square off when the Astros' Justin Verlander faces the White Sox' Dylan Cease in a scintillating pitching matchup on Tuesday at Guaranteed Rate Field in Chicago. Verlander (15-3, 1.85 ERA) leads the majors in wins, ERA and WHIP (0.86). Meanwhile Cease (12-5, 1.96) ranks third in ERA and strikeouts (174). 

Houston is a -125 favorite in the latest Astros vs. White Sox odds from Caesars Sportsbook while Chicago is a +105 underdog. First pitch is set for 8:10 p.m. ET. The game is one of 15 on the MLB schedule for Tuesday. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is a 300-260 on top-rated MLB money-line picks since the start of the 2021 season. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win the World Series. Anybody who has followed the model has seen profitable returns.

Now, the model has set its sights on the MLB schedule for Tuesday, Aug. 16. Using its top picks for the day, the model has generated a four-leg parlay that would pay more than 20-1! The parlay doesn't start until 7:20 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the picks is the Mets (+140) to beat the Braves. But the model has three other picks, including a play on a big American League underdog! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of well over 20-1? ... Join SportsLine right now to find out which picks you should be all over on Tuesday, all from the model that is on a 300-260 run on top-rated MLB money-line picks since the start of 2021!