A Big 12 battle is on tap between the No. 19 Iowa State Cyclones and the No. 22 TCU Horned Frogs at 9 p.m. ET on Wednesday at the James H. Hilton Coliseum. The Cyclones are 16-8 overall and 12-1 at home, while TCU is 17-8 overall and 2-5 on the road. The Cyclones are favored by 4 points in the latest Iowa State vs. TCU odds from Caesars Sportsbook, and the over/under is set at 134.5. Before you make any TCU vs. Iowa State picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. The model enters Week 15 of the season 66-38 on all top-rated college basketball picks this season, returning almost $1,700 for $100 players. Anybody who has followed it has seen huge returns.

Now, it has simulated Iowa State vs. TCU 10,000 times and the results are in. We can tell you that the model is leaning Over and it's also generated a point-spread pick that is hitting in over 60% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Iowa State vs. TCU? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!