The Detroit Lions and Buffalo Bills open their preseason schedules on Friday. Kickoff in Detroit is set for 7 p.m. ET. The Lions are favored by one in the latest Bills vs. Lions odds from Caesars Sportsbook, while the over-under is 36.5.

Before you make any Bills vs. Lions picks or any other NFL predictions, you NEED to see what Detroit expert R.J. White has to say.

CBS Sports' Fantasy and gambling editor, White ended the 2020 season on an 80-59 run on all NFL picks, returning more than $1,400 during that span. It's no surprise, as White has cashed huge twice in the world's most prestigious football handicapping competition, the Las Vegas SuperContest.

In addition White has gone an AMAZING 40-22-2 on his last 64 picks involving the Lions! Anyone who has followed him is WAY UP.

For Bills vs. Lions, we can tell you White is leaning Over, but his much stronger play is on the spread. In fact, White has found a crucial X-factor that has him going BIG on one side! You ABSOLUTELY need to see it before locking in your own picks.

Who wins Bills vs. Lions on Friday? And which crucial X-factor makes one side of the spread hit HARD? ... Join SportsLine right now to see which side of the Bills vs. Lions spread to jump on, all from the expert who's an outstanding 40-22-2 on Lions picks!